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- Mycophenolate_mofetil abstract "Mycophenolate mofetil (MMF) (brand name CellCept, compare with Myfortic - natrii mycophenolas) is an immunosuppressant and prodrug of mycophenolic acid, used extensively in transplant medicine. It is a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) in purine (guanine) biosynthesis which is necessary for the growth of T cells and B cells. Other cells are able to recover purines via a separate salvage pathway and are thus able to escape the effect.MMF is also used in the treatment of autoimmune diseases, such as Behçet's disease, pemphigus vulgaris, systemic lupus erythematosus and refractory incomplete lupus erythematosus. Suppressing T cells and B cells stops them from attacking healthy cells, but also weakens their ability to defend against infections.MMF became popular as a less toxic alternative, instead of or in addition to azathioprine and cyclophosphamide.The chemical name for mycophenolate mofetil is 2-morpholinoethyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoate. Its empirical formula is C23H31NO7 and molecular weight 433.50. Mycophenolate mofetil is morpholinoethyl ester of mycophenolic acid, which is used to mask the carboxyl group. Mycophenolate mofetil is reported to have pKa values 5.6 for the morpholino moiety and 8.5 for the phenolic group.".
- Mycophenolate_mofetil bioavailability "94.0".
- Mycophenolate_mofetil chEBI "8764".
- Mycophenolate_mofetil drugbank "DB00688".
- Mycophenolate_mofetil iupacName "2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate".
- Mycophenolate_mofetil pubchem "5281078".
- Mycophenolate_mofetil thumbnail Mycophenolate_mofetil2DACS.svg?width=300.
- Mycophenolate_mofetil wikiPageID "5809815".
- Mycophenolate_mofetil wikiPageRevisionID "597307518".
- Mycophenolate_mofetil bioavailability "94.0".
- Mycophenolate_mofetil c "23".
- Mycophenolate_mofetil casno "128794".
- Mycophenolate_mofetil chebi "8764".
- Mycophenolate_mofetil chembl "1456".
- Mycophenolate_mofetil chemspiderid "4444535".
- Mycophenolate_mofetil drugbank "DB00688".
- Mycophenolate_mofetil eliminationHalfLife "23400.0".
- Mycophenolate_mofetil excretion "Urine , faeces".
- Mycophenolate_mofetil h "31".
- Mycophenolate_mofetil hasPhotoCollection Mycophenolate_mofetil.
- Mycophenolate_mofetil image "Mycophenolate mofetil ball-and-stick.png".
- Mycophenolate_mofetil inchi "1".
- Mycophenolate_mofetil inchikey "RTGDFNSFWBGLEC-SYZQJQIIBO".
- Mycophenolate_mofetil iupacName "2".
- Mycophenolate_mofetil kegg "7908.0".
- Mycophenolate_mofetil legalAu "S4".
- Mycophenolate_mofetil legalCa "Rx-only".
- Mycophenolate_mofetil legalUk "POM".
- Mycophenolate_mofetil legalUs "Rx-only".
- Mycophenolate_mofetil licenceEu "CellCept".
- Mycophenolate_mofetil licenceUs "Mycophenolate_mofetil".
- Mycophenolate_mofetil medlineplus "a601081".
- Mycophenolate_mofetil metabolism "Hepatic".
- Mycophenolate_mofetil molecularWeight "433.49474".
- Mycophenolate_mofetil n "1".
- Mycophenolate_mofetil o "7".
- Mycophenolate_mofetil pregnancyAu "D".
- Mycophenolate_mofetil pregnancyUs "D".
- Mycophenolate_mofetil proteinBound "82".
- Mycophenolate_mofetil pubchem "5281078".
- Mycophenolate_mofetil routesOfAdministration "Oral, intravenous".
- Mycophenolate_mofetil smiles "CC1=COC".
- Mycophenolate_mofetil stdinchi "1".
- Mycophenolate_mofetil stdinchikey "RTGDFNSFWBGLEC-SYZQJQIISA-N".
- Mycophenolate_mofetil tradename "CellCept".
- Mycophenolate_mofetil verifiedfields "changed".
- Mycophenolate_mofetil verifiedrevid "476999346".
- Mycophenolate_mofetil width "250".
- Mycophenolate_mofetil subject Category:Immunosuppressants.
- Mycophenolate_mofetil subject Category:Isobenzofurans.
- Mycophenolate_mofetil subject Category:Lactones.
- Mycophenolate_mofetil subject Category:Morpholines.
- Mycophenolate_mofetil subject Category:Phenol_ethers.
- Mycophenolate_mofetil subject Category:Phenols.
- Mycophenolate_mofetil type Abstraction100002137.
- Mycophenolate_mofetil type Chemical114806838.
- Mycophenolate_mofetil type Compound114818238.
- Mycophenolate_mofetil type Element114840755.
- Mycophenolate_mofetil type Material114580897.
- Mycophenolate_mofetil type Matter100020827.
- Mycophenolate_mofetil type OrganicCompound114727670.
- Mycophenolate_mofetil type Part113809207.
- Mycophenolate_mofetil type Phenol114989545.
- Mycophenolate_mofetil type PhenolEthers.
- Mycophenolate_mofetil type Phenols.
- Mycophenolate_mofetil type PhysicalEntity100001930.
- Mycophenolate_mofetil type Quintessence114847103.
- Mycophenolate_mofetil type Relation100031921.
- Mycophenolate_mofetil type Substance100019613.
- Mycophenolate_mofetil type Drug.
- Mycophenolate_mofetil type FunctionalSubstance.
- Mycophenolate_mofetil comment "Mycophenolate mofetil (MMF) (brand name CellCept, compare with Myfortic - natrii mycophenolas) is an immunosuppressant and prodrug of mycophenolic acid, used extensively in transplant medicine. It is a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) in purine (guanine) biosynthesis which is necessary for the growth of T cells and B cells.".
- Mycophenolate_mofetil label "Micofenolato mofetile".
- Mycophenolate_mofetil label "Mofetil micofenolato".
- Mycophenolate_mofetil label "Mycophenolat-Mofetil".
- Mycophenolate_mofetil label "Mycophenolate mofetil".
- Mycophenolate_mofetil label "Mykofenolan mofetylu".
- Mycophenolate_mofetil label "Микофенолата мофетил".
- Mycophenolate_mofetil sameAs Mycophenolat-Mofetil.
- Mycophenolate_mofetil sameAs Micofenolato_mofetile.
- Mycophenolate_mofetil sameAs Mykofenolan_mofetylu.
- Mycophenolate_mofetil sameAs Mofetil_micofenolato.
- Mycophenolate_mofetil sameAs m.08097bk.
- Mycophenolate_mofetil sameAs Q4567614.
- Mycophenolate_mofetil sameAs Q4567614.
- Mycophenolate_mofetil sameAs DB00688.
- Mycophenolate_mofetil sameAs Mycophenolate_mofetil.
- Mycophenolate_mofetil wasDerivedFrom Mycophenolate_mofetil?oldid=597307518.
- Mycophenolate_mofetil depiction Mycophenolate_mofetil2DACS.svg.
- Mycophenolate_mofetil isPrimaryTopicOf Mycophenolate_mofetil.