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- N-Nitroso-N-methylurea abstract "N-Nitroso-N-methylurea (NMU) is a highly reliable carcinogen, mutagen, and teratogen. NMU is an alkylating agent, and exhibits its toxicity by transferring its methyl group to nucleobases in nucleic acids, which can lead to AT:GC transition mutations.NMU is the traditional precursor in the synthesis of diazomethane. However, since it is unstable at temperatures beyond 20 °C and shock-sensitive to a degree, for this purpose it has become obsolete and replaced by other (N-methyl)nitrosamides. Most chemical supply houses have stopped carrying it.Acute exposure to NMU in humans can result in skin and eye irritation, headache, nausea, and vomiting. NMU is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity in experimental animals (IARC 1972, 1978, 1987). Various cancers induced in animal models include: squamous cell carcinomas of the forestomach, sarcomas and gliomas of the brain, adenocarcinomas of the pancreas, leukemia, and lymphomas. However, the actual potential for human exposure is quite limited, as the chemical is not produced or used in large quantities NMU is teratogenic and embryotoxic, resulting in craniofacial (cleft palate) and skeletal defects, increased fetal resorption, and fetal growth retardation. Exposure to NMU during pre-implantation, post-implantation, organogenesis, or by paternal exposure can result in these effects.".
- N-Nitroso-N-methylurea iupacName "1-Methyl-1-nitrosourea".
- N-Nitroso-N-methylurea thumbnail N-Methyl_N-nitroso_urea_structure.svg?width=300.
- N-Nitroso-N-methylurea wikiPageID "20499441".
- N-Nitroso-N-methylurea wikiPageRevisionID "602858180".
- N-Nitroso-N-methylurea hasPhotoCollection N-Nitroso-N-methylurea.
- N-Nitroso-N-methylurea imagefile "N-Methyl N-nitroso urea structure.svg".
- N-Nitroso-N-methylurea imagefilel "N-nitroso-N-methylurea-from-xtal-3D-balls.png".
- N-Nitroso-N-methylurea imagefiler "N-nitroso-N-methylurea-from-xtal-3D-vdW.png".
- N-Nitroso-N-methylurea imagename "Skeletal formula of N-nitroso-N-methylurea".
- N-Nitroso-N-methylurea imagenamel "Ball and stick model of N-nitroso-N-methylurea".
- N-Nitroso-N-methylurea imagenamer "Spacefill model of N-nitroso-N-methylurea".
- N-Nitroso-N-methylurea imagesize "100".
- N-Nitroso-N-methylurea iupacname "1".
- N-Nitroso-N-methylurea name "N-Nitroso-N-methylurea".
- N-Nitroso-N-methylurea verifiedfields "changed".
- N-Nitroso-N-methylurea verifiedrevid "433348593".
- N-Nitroso-N-methylurea watchedfields "changed".
- N-Nitroso-N-methylurea subject Category:Carcinogens.
- N-Nitroso-N-methylurea subject Category:Embryotoxicants.
- N-Nitroso-N-methylurea subject Category:IARC_Group_2A_carcinogens.
- N-Nitroso-N-methylurea subject Category:Male-mediated_teratogens.
- N-Nitroso-N-methylurea subject Category:Mutagens.
- N-Nitroso-N-methylurea subject Category:Nitrosamines.
- N-Nitroso-N-methylurea subject Category:Nitrosoureas.
- N-Nitroso-N-methylurea subject Category:Teratogens.
- N-Nitroso-N-methylurea subject Category:Ureas.
- N-Nitroso-N-methylurea type Abstraction100002137.
- N-Nitroso-N-methylurea type Chemical114806838.
- N-Nitroso-N-methylurea type Cognition100023271.
- N-Nitroso-N-methylurea type Compound105870180.
- N-Nitroso-N-methylurea type Compound114818238.
- N-Nitroso-N-methylurea type Concept105835747.
- N-Nitroso-N-methylurea type Content105809192.
- N-Nitroso-N-methylurea type Idea105833840.
- N-Nitroso-N-methylurea type Material114580897.
- N-Nitroso-N-methylurea type Matter100020827.
- N-Nitroso-N-methylurea type NitrosoCompounds.
- N-Nitroso-N-methylurea type OrganicCompound114727670.
- N-Nitroso-N-methylurea type Part113809207.
- N-Nitroso-N-methylurea type PhysicalEntity100001930.
- N-Nitroso-N-methylurea type PsychologicalFeature100023100.
- N-Nitroso-N-methylurea type Relation100031921.
- N-Nitroso-N-methylurea type Substance100019613.
- N-Nitroso-N-methylurea type Urea115085472.
- N-Nitroso-N-methylurea type Ureas.
- N-Nitroso-N-methylurea type Whole105869584.
- N-Nitroso-N-methylurea type ChemicalCompound.
- N-Nitroso-N-methylurea type ChemicalSubstance.
- N-Nitroso-N-methylurea type ChemicalSubstanceType.
- N-Nitroso-N-methylurea type ChemicalObject.
- N-Nitroso-N-methylurea type Thing.
- N-Nitroso-N-methylurea comment "N-Nitroso-N-methylurea (NMU) is a highly reliable carcinogen, mutagen, and teratogen. NMU is an alkylating agent, and exhibits its toxicity by transferring its methyl group to nucleobases in nucleic acids, which can lead to AT:GC transition mutations.NMU is the traditional precursor in the synthesis of diazomethane. However, since it is unstable at temperatures beyond 20 °C and shock-sensitive to a degree, for this purpose it has become obsolete and replaced by other (N-methyl)nitrosamides.".
- N-Nitroso-N-methylurea label "N-Methyl-N-nitrosoharnstoff".
- N-Nitroso-N-methylurea label "N-Nitroso-N-methylurea".
- N-Nitroso-N-methylurea label "N-méthyl-N-nitrosourée".
- N-Nitroso-N-methylurea label "N-Нитрозо-N-метилмочевина".
- N-Nitroso-N-methylurea sameAs N-Methyl-N-nitrosoharnstoff.
- N-Nitroso-N-methylurea sameAs N-méthyl-N-nitrosourée.
- N-Nitroso-N-methylurea sameAs m.02r9gbw.
- N-Nitroso-N-methylurea sameAs Q3023727.
- N-Nitroso-N-methylurea sameAs Q3023727.
- N-Nitroso-N-methylurea sameAs N-Nitroso-N-methylurea.
- N-Nitroso-N-methylurea wasDerivedFrom N-Nitroso-N-methylurea?oldid=602858180.
- N-Nitroso-N-methylurea depiction N-Methyl_N-nitroso_urea_structure.svg.
- N-Nitroso-N-methylurea isPrimaryTopicOf N-Nitroso-N-methylurea.
- N-Nitroso-N-methylurea name "N-Nitroso-N-methylurea".
