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- NEDD9 abstract "Enhancer of filamentation 1 is a protein that in humans is encoded by the NEDD9 gene.Synonyms are CASL, HEF1, p105CAS.It is a member of the CAS (Crk-associated substrates) family.It is organized into domains, from N to C terminus: SH3 domain, SH2-binding substrate domain (which when phosphorylated binds SH2 domains), serine-rich domain, SBD (putative Src-binding domain), and a C-terminal domain that binds GEF (GDP-exchange factor) proteins of the NSP (Novel SH2 domain containing Protein) family such as BCAR3. It is believed that when tyrosine in the SBD is phosphorylated by FAK, it binds to the inhibitory domain of c-Src which is thus activated and phosphorylates tyrosines in the substrate domain of NEDD9, creating a binding site for c-Crk and activating pathways leading the cells to survival, proliferation, motility,and invasion (promoting growth and metastasis).".
- NEDD9 entrezgene "4739".
- NEDD9 wikiPageID "14754711".
- NEDD9 wikiPageRevisionID "592624021".
- NEDD9 hasPhotoCollection NEDD9.
- NEDD9 requireManualInspection "no".
- NEDD9 updateCitations "yes".
- NEDD9 updatePage "yes".
- NEDD9 updateProteinBox "yes".
- NEDD9 updateSummary "yes".
- NEDD9 subject Category:Human_proteins.
- NEDD9 type Biomolecule.
- NEDD9 type Protein.
- NEDD9 type BiologicalObject.
- NEDD9 comment "Enhancer of filamentation 1 is a protein that in humans is encoded by the NEDD9 gene.Synonyms are CASL, HEF1, p105CAS.It is a member of the CAS (Crk-associated substrates) family.It is organized into domains, from N to C terminus: SH3 domain, SH2-binding substrate domain (which when phosphorylated binds SH2 domains), serine-rich domain, SBD (putative Src-binding domain), and a C-terminal domain that binds GEF (GDP-exchange factor) proteins of the NSP (Novel SH2 domain containing Protein) family such as BCAR3. ".
- NEDD9 label "NEDD9".
- NEDD9 sameAs m.03gwrlj.
- NEDD9 sameAs Q6953445.
- NEDD9 sameAs Q6953445.
- NEDD9 wasDerivedFrom NEDD9?oldid=592624021.
- NEDD9 isPrimaryTopicOf NEDD9.