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- NHL_repeat abstract "The NHL repeat, named after NCL-1, HT2A and Lin-41, is an amino acid sequence found largely in a large number of eukaryotic and prokaryotic proteins. For example, the repeat is found in a variety of enzymes of the copper type II, ascorbate-dependent monooxygenase family which catalyse the C-terminus alpha-amidation of biological peptides. In many it occurs in tandem arrays, for example in the RING finger beta-box, coiled-coil (RBCC) eukaryotic growth regulators. The 'Brain Tumor' protein (Brat) is one such growth regulator that contains a 6-bladed NHL-repeat beta-propeller.The NHL repeats are also found in serine/threonine protein kinase (STPK) in diverse range of pathogenic bacteria. These STPK are transmembrane receptors with an intracellular N-terminal kinase domain and extracellular C-terminal sensor domain. In the STPK, PknD, from Mycobacterium tuberculosis, the sensor domain forms a rigid, six-bladed b-propeller composed of NHL repeats with a flexible tether to the transmembrane domain.".
- NHL_repeat symbol "NHL".
- NHL_repeat thumbnail PDB_1q7f_EBI.jpg?width=300.
- NHL_repeat wikiPageID "27414879".
- NHL_repeat wikiPageRevisionID "592646291".
- NHL_repeat caption "Structure of the brain tumor-Pumilio translation repressor complex.".
- NHL_repeat hasPhotoCollection NHL_repeat.
- NHL_repeat interpro "IPR001258".
- NHL_repeat name "NHL repeat".
- NHL_repeat pdb ", ,".
- NHL_repeat pfam "PF01436".
- NHL_repeat pfamClan "CL0186".
- NHL_repeat scop "1".
- NHL_repeat symbol "NHL".
- NHL_repeat subject Category:Proteins.
- NHL_repeat type Abstraction100002137.
- NHL_repeat type Chemical114806838.
- NHL_repeat type Compound114818238.
- NHL_repeat type Macromolecule114944888.
- NHL_repeat type Material114580897.
- NHL_repeat type Matter100020827.
- NHL_repeat type Molecule114682133.
- NHL_repeat type OrganicCompound114727670.
- NHL_repeat type Part113809207.
- NHL_repeat type PhysicalEntity100001930.
- NHL_repeat type Protein114728724.
- NHL_repeat type Proteins.
- NHL_repeat type Relation100031921.
- NHL_repeat type Substance100019613.
- NHL_repeat type Thing100002452.
- NHL_repeat type Unit109465459.
- NHL_repeat type Biomolecule.
- NHL_repeat type Protein.
- NHL_repeat type BiologicalObject.
- NHL_repeat comment "The NHL repeat, named after NCL-1, HT2A and Lin-41, is an amino acid sequence found largely in a large number of eukaryotic and prokaryotic proteins. For example, the repeat is found in a variety of enzymes of the copper type II, ascorbate-dependent monooxygenase family which catalyse the C-terminus alpha-amidation of biological peptides. In many it occurs in tandem arrays, for example in the RING finger beta-box, coiled-coil (RBCC) eukaryotic growth regulators.".
- NHL_repeat label "NHL repeat".
- NHL_repeat sameAs m.0b__kkj.
- NHL_repeat sameAs Q6954084.
- NHL_repeat sameAs Q6954084.
- NHL_repeat sameAs NHL_repeat.
- NHL_repeat wasDerivedFrom NHL_repeat?oldid=592646291.
- NHL_repeat depiction PDB_1q7f_EBI.jpg.
- NHL_repeat isPrimaryTopicOf NHL_repeat.
