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- NIH_shift abstract "An NIH shift is a chemical rearrangement where a hydrogen atom on an aromatic ring undergoes an intramolecular migration primarily during a hydroxylation reaction. This process is also known as a 1,2-hydride shift. These shifts are often studied and observed by isotopic labeling. An example of an NIH shift is shown below:In this example, a hydrogen atom has been isotopically labeled using deuterium (shown in red). As the hydroxylase adds a hydroxyl (the −OH group), the labeled site shifts one position around the aromatic ring relative to the stationary methyl group (−CH3).Several hydroxylase enzymes are believed to incorporate an NIH shift in their mechanism, including 4-hydroxyphenylpyruvate dioxygenase and the tetrahydrobiopterin dependent hydroxylases. The name NIH shift arises from the US National Institutes of Health from where studies first reported observing this transformation.".
- NIH_shift thumbnail Gen_NIH_shift.png?width=300.
- NIH_shift wikiPageID "4535333".
- NIH_shift wikiPageRevisionID "556951068".
- NIH_shift hasPhotoCollection NIH_shift.
- NIH_shift subject Category:Enzymes.
- NIH_shift subject Category:Posttranslational_modification.
- NIH_shift subject Category:Reaction_mechanisms.
- NIH_shift type Abstraction100002137.
- NIH_shift type Activator114723079.
- NIH_shift type Catalyst114723628.
- NIH_shift type Chemical114806838.
- NIH_shift type Compound114818238.
- NIH_shift type Enzyme114732946.
- NIH_shift type Enzymes.
- NIH_shift type Macromolecule114944888.
- NIH_shift type Material114580897.
- NIH_shift type Matter100020827.
- NIH_shift type Molecule114682133.
- NIH_shift type OrganicCompound114727670.
- NIH_shift type Part113809207.
- NIH_shift type PhysicalEntity100001930.
- NIH_shift type Protein114728724.
- NIH_shift type Relation100031921.
- NIH_shift type Substance100019613.
- NIH_shift type Thing100002452.
- NIH_shift type Unit109465459.
- NIH_shift comment "An NIH shift is a chemical rearrangement where a hydrogen atom on an aromatic ring undergoes an intramolecular migration primarily during a hydroxylation reaction. This process is also known as a 1,2-hydride shift. These shifts are often studied and observed by isotopic labeling. An example of an NIH shift is shown below:In this example, a hydrogen atom has been isotopically labeled using deuterium (shown in red).".
- NIH_shift label "NIH shift".
- NIH_shift label "NIH重排反应".
- NIH_shift sameAs m.0c7n52.
- NIH_shift sameAs Q6954318.
- NIH_shift sameAs Q6954318.
- NIH_shift sameAs NIH_shift.
- NIH_shift wasDerivedFrom NIH_shift?oldid=556951068.
- NIH_shift depiction Gen_NIH_shift.png.
- NIH_shift isPrimaryTopicOf NIH_shift.
