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- NUDT1 abstract "7,8-dihydro-8-oxoguanine triphosphatase is an enzyme that in humans is encoded by the NUDT1 gene.Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.".
- NUDT1 entrezgene "4521".
- NUDT1 wikiPageID "14762103".
- NUDT1 wikiPageRevisionID "592680064".
- NUDT1 hasPhotoCollection NUDT1.
- NUDT1 requireManualInspection "no".
- NUDT1 summaryText "Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform has been described.".
- NUDT1 updateCitations "yes".
- NUDT1 updatePage "yes".
- NUDT1 updateProteinBox "yes".
- NUDT1 updateSummary "yes".
- NUDT1 type Biomolecule.
- NUDT1 type Protein.
- NUDT1 type BiologicalObject.
- NUDT1 comment "7,8-dihydro-8-oxoguanine triphosphatase is an enzyme that in humans is encoded by the NUDT1 gene.Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration.".
- NUDT1 label "NUDT1".
- NUDT1 sameAs m.03gx2zc.
- NUDT1 sameAs Q6955576.
- NUDT1 sameAs Q6955576.
- NUDT1 wasDerivedFrom NUDT1?oldid=592680064.
- NUDT1 isPrimaryTopicOf NUDT1.