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- NUP98 abstract "Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene.Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is composed of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.".
- NUP98 entrezgene "4928".
- NUP98 wikiPageID "14130525".
- NUP98 wikiPageRevisionID "592681969".
- NUP98 hasPhotoCollection NUP98.
- NUP98 requireManualInspection "no".
- NUP98 summaryText "Signal-mediated nuclear import and export proceed through the nuclear pore complex , which is composed of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocatons in acute myelogenous leukemia and T-cell acute lymphocytic leukemia . This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.".
- NUP98 updateCitations "yes".
- NUP98 updatePage "yes".
- NUP98 updateProteinBox "yes".
- NUP98 updateSummary "yes".
- NUP98 type Biomolecule.
- NUP98 type Protein.
- NUP98 type BiologicalObject.
- NUP98 comment "Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene.Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is composed of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein.".
- NUP98 label "NUP98".
- NUP98 sameAs m.03cvhs7.
- NUP98 sameAs Q6955623.
- NUP98 sameAs Q6955623.
- NUP98 wasDerivedFrom NUP98?oldid=592681969.
- NUP98 isPrimaryTopicOf NUP98.