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- Neurohypophysial_hormone abstract "The neurohypophysial hormones form a family of structurally and functionally related peptide hormones. Their main representatives are oxytocin and vasopressin. They are named for being secreted by the neurohypophysis, i.e. the posterior pituitary gland (hypophysis refers to the pituitary gland), itself a neuronal projection from the hypothalamus.Most of the circulating oxytocin and vasopressin hormones are synthesized in magnocellular neurosecretory cells of the supraoptic nucleus and paraventricular nucleus of the hypothalamus. They are then transported in neurosecretory granules along axons within the hypothalamo-neurohypophysial tract by axoplasmic flow to axon terminals forming the pars nervosa of the posterior pituitary. There, they are stored in Herring bodies and can be released into the circulation on the basis of hormonal and synaptic signals with assistance from pituicytes.Vasopressin and oxytocin are also synthesized in the parvocellular neurosecretory cells of the paraventricular nucleus of the hypothalamus, which project to the median eminence, where they are transported and secreted into the hypophyseal portal system to stimulate the anterior pituitary. Thus they can also be considered as hypophysiotropic hormones.Oxytocin mediates contraction of the smooth muscle of the uterus and mammary gland, while vasopressin has antidiuretic action on the kidney, and mediates vasoconstriction of the peripheral vessels. Due to the similarity of the two hormones, there is cross-reaction: oxytocin has a slight antidiuretic function, and high levels of AVP can cause uterine contractions. In common with most active peptides, both hormones are synthesised as larger protein precursors that are enzymatically converted to their mature forms. Members of this family are found in birds, fish, reptiles and amphibians (mesotocin, isotocin, valitocin, glumitocin, aspargtocin, vasotocin, seritocin, asvatocin, phasvatocin), in worms (annetocin), octopi (cephalotocin), Locusta migratoria (Migratory locust) (locupressin or neuropeptide F1/F2) and in molluscs (conopressins G and S).".
- Neurohypophysial_hormone symbol "Hormone_4".
- Neurohypophysial_hormone symbol "Hormone_5".
- Neurohypophysial_hormone thumbnail PDB_1xy1_EBI.jpg?width=300.
- Neurohypophysial_hormone wikiPageID "29126466".
- Neurohypophysial_hormone wikiPageRevisionID "593805189".
- Neurohypophysial_hormone caption "crystal structure analysis of deamino-oxytocin. conformational flexibility and receptor binding".
- Neurohypophysial_hormone caption "solution structure of the monomeric form of a mutant unliganded bovine neurophysin, minimized average structure".
- Neurohypophysial_hormone hasPhotoCollection Neurohypophysial_hormone.
- Neurohypophysial_hormone interpro "IPR000981".
- Neurohypophysial_hormone interpro "IPR022423".
- Neurohypophysial_hormone name "Neurohypophysial hormones, C-terminal Domain".
- Neurohypophysial_hormone name "Neurohypophysial hormones, N-terminal Domain".
- Neurohypophysial_hormone pfam "PF00184".
- Neurohypophysial_hormone pfam "PF00220".
- Neurohypophysial_hormone prosite "PDOC00237".
- Neurohypophysial_hormone scop "1".
- Neurohypophysial_hormone symbol "Hormone_4".
- Neurohypophysial_hormone symbol "Hormone_5".
- Neurohypophysial_hormone subject Category:Hormones.
- Neurohypophysial_hormone subject Category:Peptides.
- Neurohypophysial_hormone subject Category:Protein_families.
- Neurohypophysial_hormone type Abstraction100002137.
- Neurohypophysial_hormone type Amide114724264.
- Neurohypophysial_hormone type BodySubstance105263850.
- Neurohypophysial_hormone type Chemical114806838.
- Neurohypophysial_hormone type Compound114818238.
- Neurohypophysial_hormone type Hormone105407119.
- Neurohypophysial_hormone type Hormones.
- Neurohypophysial_hormone type LiquidBodySubstance105397468.
- Neurohypophysial_hormone type Material114580897.
- Neurohypophysial_hormone type Matter100020827.
- Neurohypophysial_hormone type OrganicCompound114727670.
- Neurohypophysial_hormone type Part113809207.
- Neurohypophysial_hormone type Peptide114743046.
- Neurohypophysial_hormone type Peptides.
- Neurohypophysial_hormone type PhysicalEntity100001930.
- Neurohypophysial_hormone type Relation100031921.
- Neurohypophysial_hormone type Secretion105404728.
- Neurohypophysial_hormone type Substance100019613.
- Neurohypophysial_hormone type Biomolecule.
- Neurohypophysial_hormone type Protein.
- Neurohypophysial_hormone type BiologicalObject.
- Neurohypophysial_hormone comment "The neurohypophysial hormones form a family of structurally and functionally related peptide hormones. Their main representatives are oxytocin and vasopressin. They are named for being secreted by the neurohypophysis, i.e.".
- Neurohypophysial_hormone label "Neurohypophysial hormone".
- Neurohypophysial_hormone label "هرمونات نخامية عصبية".
- Neurohypophysial_hormone sameAs m.0dlkfn9.
- Neurohypophysial_hormone sameAs Q7002289.
- Neurohypophysial_hormone sameAs Q7002289.
- Neurohypophysial_hormone sameAs Neurohypophysial_hormone.
- Neurohypophysial_hormone wasDerivedFrom Neurohypophysial_hormone?oldid=593805189.
- Neurohypophysial_hormone depiction PDB_1xy1_EBI.jpg.
- Neurohypophysial_hormone isPrimaryTopicOf Neurohypophysial_hormone.