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- Neuropeptide_S_receptor abstract "The neuropeptide S receptor (NPSR) is a member of the G-protein coupled receptor superfamily of integral membrane proteins which binds neuropeptide S (NPS). It was formerly an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous ligand.In the CNS, activation of the NPSR by NPS promotes arousal and anxiolytic-like effects.In addition, mututations in NPSR have been linked to a susceptibility to asthma. Hence NPSR has also been called GPRA (G protein-coupled receptor for asthma susceptibility). Activation of NPSR in the airway epithelium has a number of effects including upregulation of matrix metalloproteinases which are involved in the pathogenesis of asthma.This gene is a member of the G protein-coupled receptor 1 family and encodes a plasma membrane protein. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Mutations in this gene have also been associated with this disease. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.".
- Neuropeptide_S_receptor entrezgene "387129".
- Neuropeptide_S_receptor wikiPageExternalLink ChapterMenuForward?chapterID=1324.
- Neuropeptide_S_receptor wikiPageID "14051706".
- Neuropeptide_S_receptor wikiPageRevisionID "545020164".
- Neuropeptide_S_receptor hasPhotoCollection Neuropeptide_S_receptor.
- Neuropeptide_S_receptor requireManualInspection "no".
- Neuropeptide_S_receptor summaryText "This gene is a member of the G protein-coupled receptor 1 family and encodes a plasma membrane protein. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Mutations in this gene have also been associated with this disease. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.".
- Neuropeptide_S_receptor updateCitations "yes".
- Neuropeptide_S_receptor updatePage "yes".
- Neuropeptide_S_receptor updateProteinBox "yes".
- Neuropeptide_S_receptor updateSummary "yes".
- Neuropeptide_S_receptor subject Category:G_protein_coupled_receptors.
- Neuropeptide_S_receptor type BodyPart105220461.
- Neuropeptide_S_receptor type GProteinCoupledReceptors.
- Neuropeptide_S_receptor type Part109385911.
- Neuropeptide_S_receptor type PhysicalEntity100001930.
- Neuropeptide_S_receptor type Receptor105608868.
- Neuropeptide_S_receptor type Structure105225602.
- Neuropeptide_S_receptor type Thing100002452.
- Neuropeptide_S_receptor type Biomolecule.
- Neuropeptide_S_receptor type Protein.
- Neuropeptide_S_receptor type BiologicalObject.
- Neuropeptide_S_receptor comment "The neuropeptide S receptor (NPSR) is a member of the G-protein coupled receptor superfamily of integral membrane proteins which binds neuropeptide S (NPS). It was formerly an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous ligand.In the CNS, activation of the NPSR by NPS promotes arousal and anxiolytic-like effects.In addition, mututations in NPSR have been linked to a susceptibility to asthma.".
- Neuropeptide_S_receptor label "Neuropeptide S receptor".
- Neuropeptide_S_receptor sameAs m.03cs4h1.
- Neuropeptide_S_receptor sameAs Q7002518.
- Neuropeptide_S_receptor sameAs Q7002518.
- Neuropeptide_S_receptor sameAs 1268.
- Neuropeptide_S_receptor sameAs Neuropeptide_S_receptor.
- Neuropeptide_S_receptor wasDerivedFrom Neuropeptide_S_receptor?oldid=545020164.
- Neuropeptide_S_receptor isPrimaryTopicOf Neuropeptide_S_receptor.