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- Nitisinone abstract "Nitisinone (also known as NTBC, an abbreviation of its full chemical name) is a drug originally developed as a herbicide, now used to slow the effects of hereditary tyrosinemia type 1. Since its first use for this indication in 1991, it has replaced liver transplantation as the first-line treatment for this rare condition. It is also being studied in the related condition alkaptonuria. It is marketed under the brand name Orfadin.The mechanism of action of nitisinone involves reversibile inhibition of 4-hydroxyphenylpyruvate oxidase, thus preventing the formation of maleylacetoacetic acid and fumarylacetoacetic acid, which have the potential to be converted to succinyl acetone, a toxin that damages the liver and kidneys.Nitisinone has been shown to be a possible treatment for alkaptonuria in a mouse model and in human trials. Its effects are now studies in international clinical trials called DevelopAKUre.Nitisinone has been shown to increase skin and eye pigmentation in mice, and has been suggested as a possible treatment for oculocutaneous albinism.".
- Nitisinone atcPrefix "A16".
- Nitisinone atcSuffix "AX04".
- Nitisinone casNumber "104206-65-7".
- Nitisinone chEBI "50378".
- Nitisinone drugbank "DB00348".
- Nitisinone fdaUniiCode "K5BN214699".
- Nitisinone iupacName "2-[2-nitro-4-(trifluoromethyl)benzoyl]".
- Nitisinone iupacName "cyclohexane-1,3-dione".
- Nitisinone pubchem "115355".
- Nitisinone thumbnail Nitisinone.svg?width=300.
- Nitisinone wikiPageExternalLink www.developakure.eu.
- Nitisinone wikiPageID "8262849".
- Nitisinone wikiPageRevisionID "600883729".
- Nitisinone atcPrefix "A16".
- Nitisinone atcSuffix "AX04".
- Nitisinone c "14".
- Nitisinone casNumber "104206".
- Nitisinone chebi "50378".
- Nitisinone chembl "1337".
- Nitisinone chemspiderid "103195".
- Nitisinone drugbank "DB00348".
- Nitisinone eliminationHalfLife "194400.0".
- Nitisinone f "3".
- Nitisinone h "10".
- Nitisinone hasPhotoCollection Nitisinone.
- Nitisinone iupacName "2".
- Nitisinone iupacName "cyclohexane-1,3-dione".
- Nitisinone kegg "D05177".
- Nitisinone legalUs "Rx-only".
- Nitisinone licenceEu "Orfadin".
- Nitisinone licenceUs "Nitisinone".
- Nitisinone molecularWeight "329.228".
- Nitisinone n "1".
- Nitisinone o "5".
- Nitisinone pubchem "115355".
- Nitisinone routesOfAdministration "Oral".
- Nitisinone smiles "O=CC2CCCCC2=O".
- Nitisinone stdinchi "1".
- Nitisinone stdinchikey "OUBCNLGXQFSTLU-UHFFFAOYSA-N".
- Nitisinone unii "K5BN214699".
- Nitisinone verifiedrevid "462261617".
- Nitisinone subject Category:Aromatic_ketones.
- Nitisinone subject Category:Herbicides.
- Nitisinone subject Category:Nitrobenzenes.
- Nitisinone subject Category:Organofluorides.
- Nitisinone subject Category:Orphan_drugs.
- Nitisinone type Abstraction100002137.
- Nitisinone type AromaticKetones.
- Nitisinone type Chemical114806838.
- Nitisinone type Compound114818238.
- Nitisinone type Herbicide114906850.
- Nitisinone type Herbicides.
- Nitisinone type Ketone114926294.
- Nitisinone type Material114580897.
- Nitisinone type Matter100020827.
- Nitisinone type Nitrobenzene114963486.
- Nitisinone type Nitrobenzenes.
- Nitisinone type OrganicCompound114727670.
- Nitisinone type Part113809207.
- Nitisinone type PhysicalEntity100001930.
- Nitisinone type Relation100031921.
- Nitisinone type Substance100019613.
- Nitisinone type Drug.
- Nitisinone type DrugProduct.
- Nitisinone type FunctionalSubstance.
- Nitisinone comment "Nitisinone (also known as NTBC, an abbreviation of its full chemical name) is a drug originally developed as a herbicide, now used to slow the effects of hereditary tyrosinemia type 1. Since its first use for this indication in 1991, it has replaced liver transplantation as the first-line treatment for this rare condition. It is also being studied in the related condition alkaptonuria.".
- Nitisinone label "Nitisinon".
- Nitisinone label "Nitisinone".
- Nitisinone label "Nitisinone".
- Nitisinone label "Nityzynon".
- Nitisinone sameAs Nitisinon.
- Nitisinone sameAs Nitisinone.
- Nitisinone sameAs Nityzynon.
- Nitisinone sameAs m.026y74f.
- Nitisinone sameAs Q3877355.
- Nitisinone sameAs Q3877355.
- Nitisinone sameAs DB00348.
- Nitisinone sameAs 115355.
- Nitisinone sameAs Nitisinone.
- Nitisinone wasDerivedFrom Nitisinone?oldid=600883729.
- Nitisinone depiction Nitisinone.svg.
- Nitisinone isPrimaryTopicOf Nitisinone.
