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- Nitric_oxide_dioxygenase abstract "Nitric oxide dioxygenase (EC 1.14.12.17) is an enzyme that catalyzes the conversion of nitric oxide (NO) to nitrate (NO−3). The net reaction for the reaction catalyzed by nitric oxide dioxygenase is shown below: 2NO + 2O2 + NAD(P)H → 2NO3- + NAD(P)+ + H+Nitric oxide is a ubiquitous small molecule that is integrated in a wide variety of physiological processes including smooth muscle vasodilation, platelet disaggregation, neurotransmission, and immune response to bacterial infection. Overproduction of this signaling molecule can be lethal to cells by poisoning cellular energy production. The most sensitive targets of NO are aconitase, an enzyme that catalyzes the isomerization of citrate to isocitrate in the citric acid cycle, and cytochrome oxidase, the last enzyme in the respiratory electron transport chain of mitochondria. Additionally NO, with its lone radical on the nitrogen atom, is implicated in a number of secondary mechanisms of toxicity, including catalase inhibition (resulting in hydrogen peroxide toxicity), Fe-S center iron liberation, and the formation of dinitosyl-iron complexes.Due to the potential lethality of NO, cells benefitted greatly from the evolution of an enzyme capable of catalyzing the conversion of toxic NO to nitrate. A 'nitric oxide dioxygenase' is an enzyme that is capable of carrying out this reaction. NO dioxygenase belongs to the family of oxidoreductases, more specifically those acting on paired donors, with O2 as oxidant and with incorporation of two atoms of oxygen into the other donor.".
- Nitric_oxide_dioxygenase ecNumber "1.14.12.17".
- Nitric_oxide_dioxygenase thumbnail PDB_1gvh.jpg?width=300.
- Nitric_oxide_dioxygenase wikiPageID "14045844".
- Nitric_oxide_dioxygenase wikiPageRevisionID "592655600".
- Nitric_oxide_dioxygenase b "3".
- Nitric_oxide_dioxygenase caption "E. coli flavohemoglobin/NOD structure. green = reductase domain, blue = hemoglobin domain.".
- Nitric_oxide_dioxygenase casNumber "214466".
- Nitric_oxide_dioxygenase ecNumber "1.14".
- Nitric_oxide_dioxygenase goCode "8941".
- Nitric_oxide_dioxygenase hasPhotoCollection Nitric_oxide_dioxygenase.
- Nitric_oxide_dioxygenase iubmbEcNumber "1".
- Nitric_oxide_dioxygenase name "nitric oxide dioxygenase".
- Nitric_oxide_dioxygenase p "−".
- Nitric_oxide_dioxygenase subject Category:EC_1.14.12.
- Nitric_oxide_dioxygenase subject Category:Enzymes_of_unknown_structure.
- Nitric_oxide_dioxygenase subject Category:NADH-dependent_enzymes.
- Nitric_oxide_dioxygenase subject Category:NADPH-dependent_enzymes.
- Nitric_oxide_dioxygenase type Abstraction100002137.
- Nitric_oxide_dioxygenase type Activator114723079.
- Nitric_oxide_dioxygenase type Catalyst114723628.
- Nitric_oxide_dioxygenase type Chemical114806838.
- Nitric_oxide_dioxygenase type Compound114818238.
- Nitric_oxide_dioxygenase type Enzyme114732946.
- Nitric_oxide_dioxygenase type EnzymesOfUnknownStructure.
- Nitric_oxide_dioxygenase type Macromolecule114944888.
- Nitric_oxide_dioxygenase type Material114580897.
- Nitric_oxide_dioxygenase type Matter100020827.
- Nitric_oxide_dioxygenase type Molecule114682133.
- Nitric_oxide_dioxygenase type NADH-dependentEnzymes.
- Nitric_oxide_dioxygenase type NADPH-dependentEnzymes.
- Nitric_oxide_dioxygenase type OrganicCompound114727670.
- Nitric_oxide_dioxygenase type Part113809207.
- Nitric_oxide_dioxygenase type PhysicalEntity100001930.
- Nitric_oxide_dioxygenase type Protein114728724.
- Nitric_oxide_dioxygenase type Relation100031921.
- Nitric_oxide_dioxygenase type Substance100019613.
- Nitric_oxide_dioxygenase type Thing100002452.
- Nitric_oxide_dioxygenase type Unit109465459.
- Nitric_oxide_dioxygenase type Biomolecule.
- Nitric_oxide_dioxygenase type Enzyme.
- Nitric_oxide_dioxygenase type BiologicalObject.
- Nitric_oxide_dioxygenase comment "Nitric oxide dioxygenase (EC 1.14.12.17) is an enzyme that catalyzes the conversion of nitric oxide (NO) to nitrate (NO−3). The net reaction for the reaction catalyzed by nitric oxide dioxygenase is shown below: 2NO + 2O2 + NAD(P)H → 2NO3- + NAD(P)+ + H+Nitric oxide is a ubiquitous small molecule that is integrated in a wide variety of physiological processes including smooth muscle vasodilation, platelet disaggregation, neurotransmission, and immune response to bacterial infection.".
- Nitric_oxide_dioxygenase label "Nitric oxide dioxygenase".
- Nitric_oxide_dioxygenase label "Ossido nitrico diossigenasi".
- Nitric_oxide_dioxygenase label "حمض النتريك دي-أكسجيناز".
- Nitric_oxide_dioxygenase label "一酸化窒素ジオキシゲナーゼ".
- Nitric_oxide_dioxygenase sameAs Ossido_nitrico_diossigenasi.
- Nitric_oxide_dioxygenase sameAs 一酸化窒素ジオキシゲナーゼ.
- Nitric_oxide_dioxygenase sameAs m.03cr_7r.
- Nitric_oxide_dioxygenase sameAs Q3878102.
- Nitric_oxide_dioxygenase sameAs Q3878102.
- Nitric_oxide_dioxygenase sameAs Nitric_oxide_dioxygenase.
- Nitric_oxide_dioxygenase wasDerivedFrom Nitric_oxide_dioxygenase?oldid=592655600.
- Nitric_oxide_dioxygenase depiction PDB_1gvh.jpg.
- Nitric_oxide_dioxygenase isPrimaryTopicOf Nitric_oxide_dioxygenase.
- Nitric_oxide_dioxygenase name "nitric oxide dioxygenase".