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Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Nitric_oxide_synthase> ?p ?o. }

• Nitric_oxide_synthase abstract "Nitric oxide synthases (EC 1.14.13.39) (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, is involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease. NOS catalyzes the reaction: L-arginine + 3/2 NADPH + H+ + 2 O2 citrulline + nitric oxide + 3/2 NADP+NOS isoforms catalyze other leak and side reactions, such as superoxide production at the expense of NADPH. As such, this stoichiometry is not generally observed, and reflects the three electrons supplied per NO by NADPH. NOSs are unusual in that they require five cofactors. Eukaryotic NOS isozymes are catalytically self-sufficient. The electron flow in the NO synthase reaction is: NADPH → FAD → FMN → heme → O2. Tetrahydrobiopterin provides an additional electron during the catalytic cycle which is replaced during turnover. NOS is the only known enzyme that binds flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN), heme, tetrahydrobiopterin (BH4) and calmodulin.".
• Nitric_oxide_synthase ecNumber "1.14.13.39".
• Nitric_oxide_synthase thumbnail 1nsi.png?width=300.
• Nitric_oxide_synthase wikiPageExternalLink nospage.htm.
• Nitric_oxide_synthase wikiPageExternalLink 1998.
• Nitric_oxide_synthase wikiPageExternalLink Nitric_oxide_synthase.
• Nitric_oxide_synthase wikiPageID "1035417".
• Nitric_oxide_synthase wikiPageRevisionID "601719245".
• Nitric_oxide_synthase caption "Human indicible nitric oxide synthase. PDB".
• Nitric_oxide_synthase caption "Structure of endothelial nitric oxide synthase heme domain.".
• Nitric_oxide_synthase casNumber "125978".
• Nitric_oxide_synthase ecNumber "1.14".
• Nitric_oxide_synthase goCode "51767".
• Nitric_oxide_synthase hasPhotoCollection Nitric_oxide_synthase.
• Nitric_oxide_synthase interpro "IPR004030".
• Nitric_oxide_synthase iubmbEcNumber "1".
• Nitric_oxide_synthase name "Nitric oxide synthase, oxygenase domain".
• Nitric_oxide_synthase name "Nitric-oxide synthase".
• Nitric_oxide_synthase pfam "PF02898".
• Nitric_oxide_synthase scop "1".
• Nitric_oxide_synthase symbol "NO_synthase".
• Nitric_oxide_synthase subject Category:EC_1.14.13.
• Nitric_oxide_synthase subject Category:Heme-thiolate_proteins.
• Nitric_oxide_synthase type Abstraction100002137.
• Nitric_oxide_synthase type Chemical114806838.
• Nitric_oxide_synthase type Compound114818238.
• Nitric_oxide_synthase type Heme-thiolateProteins.
• Nitric_oxide_synthase type Macromolecule114944888.
• Nitric_oxide_synthase type Material114580897.
• Nitric_oxide_synthase type Matter100020827.
• Nitric_oxide_synthase type Molecule114682133.
• Nitric_oxide_synthase type OrganicCompound114727670.
• Nitric_oxide_synthase type Part113809207.
• Nitric_oxide_synthase type PhysicalEntity100001930.
• Nitric_oxide_synthase type Protein114728724.
• Nitric_oxide_synthase type Relation100031921.
• Nitric_oxide_synthase type Substance100019613.
• Nitric_oxide_synthase type Thing100002452.
• Nitric_oxide_synthase type Unit109465459.
• Nitric_oxide_synthase type Biomolecule.
• Nitric_oxide_synthase type Enzyme.
• Nitric_oxide_synthase type BiologicalObject.
• Nitric_oxide_synthase comment "Nitric oxide synthases (EC 1.14.13.39) (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter.".
• Nitric_oxide_synthase label "NO sintasi".
• Nitric_oxide_synthase label "NO-Synthasen".
• Nitric_oxide_synthase label "Nitric oxide synthase".
• Nitric_oxide_synthase label "Oxyde nitrique synthase".
• Nitric_oxide_synthase label "Syntaza tlenku azotu".
• Nitric_oxide_synthase label "Óxido nítrico sintasa".
• Nitric_oxide_synthase label "Синтаза оксида азота".
• Nitric_oxide_synthase label "حمض النتريك سينثاز".
• Nitric_oxide_synthase label "一氧化氮合酶".
• Nitric_oxide_synthase label "一酸化窒素合成酵素".
• Nitric_oxide_synthase sameAs NO-Synthasen.
• Nitric_oxide_synthase sameAs Óxido_nítrico_sintasa.
• Nitric_oxide_synthase sameAs Oxyde_nitrique_synthase.
• Nitric_oxide_synthase sameAs NO_sintasi.
• Nitric_oxide_synthase sameAs 一酸化窒素合成酵素.
• Nitric_oxide_synthase sameAs 산화질소_합성효소.
• Nitric_oxide_synthase sameAs Syntaza_tlenku_azotu.
• Nitric_oxide_synthase sameAs m.0408cj.
• Nitric_oxide_synthase sameAs Q417619.
• Nitric_oxide_synthase sameAs Q417619.
• Nitric_oxide_synthase sameAs Nitric_oxide_synthase.
• Nitric_oxide_synthase wasDerivedFrom Nitric_oxide_synthase?oldid=601719245.
• Nitric_oxide_synthase depiction 1nsi.png.
• Nitric_oxide_synthase isPrimaryTopicOf Nitric_oxide_synthase.
• Nitric_oxide_synthase name "Nitric-oxide synthase".