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- Nociceptin abstract "Nociceptin or orphanin FQ, a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor (NOP, ORL-1). It is derived from the prepronociceptin protein, as are a further 2 peptides, nocistatin & NocII. The gene coding for prepronociceptin is located on Ch8p21 in humans.Nociceptin is an opioid-related peptide, but it does not act at the classic opioid receptors (namely, mu, kappa, and delta opioid receptors), and its actions are not antagonized by the opioid antagonist naloxone. Nociceptin is a potent anti-analgesic. Nociceptin is widely distributed in the CNS; it is found in many regions of the hypothalamus, brainstem, and forebrain, as well as in the ventral horn and dorsal horn of the spinal cord. Nociceptin acts at the Nociceptin receptor (NOP1), formerly known as ORL-1. The receptor is also widely distributed in the brain, including in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala, central gray, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus, and spinal cord.The N/OFQ-NOP system is found in central and peripheral nervous tissue, where it is well-placed to modulate nociception. Indeed, there is some evidence that nociceptin may be involved in the phenomenon of opioid-induced hyperalgesia.".
- Nociceptin thumbnail Nociceptin.png?width=300.
- Nociceptin wikiPageID "4031801".
- Nociceptin wikiPageRevisionID "599129559".
- Nociceptin arm "p".
- Nociceptin band "21".
- Nociceptin chromosome "8".
- Nociceptin entrezgene "5368".
- Nociceptin hasPhotoCollection Nociceptin.
- Nociceptin hgncid "9163".
- Nociceptin imagefile "Nociceptin.png".
- Nociceptin imagesize "200".
- Nociceptin name "prepronociceptin".
- Nociceptin omim "601459".
- Nociceptin othernames "Orphanin FQ".
- Nociceptin refseq "NM_006228".
- Nociceptin symbol "PNOC".
- Nociceptin uniprot "Q13519".
- Nociceptin verifiedrevid "403683635".
- Nociceptin subject Category:Neuropeptides.
- Nociceptin subject Category:Opioid_peptides.
- Nociceptin type ChemicalCompound.
- Nociceptin type ChemicalSubstance.
- Nociceptin type ChemicalSubstanceType.
- Nociceptin type ChemicalObject.
- Nociceptin type Thing.
- Nociceptin comment "Nociceptin or orphanin FQ, a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor (NOP, ORL-1). It is derived from the prepronociceptin protein, as are a further 2 peptides, nocistatin & NocII.".
- Nociceptin label "Nociceptin".
- Nociceptin label "Ноцицептин".
- Nociceptin sameAs m.02wvbqr.
- Nociceptin sameAs Q4327722.
- Nociceptin sameAs Q4327722.
- Nociceptin wasDerivedFrom Nociceptin?oldid=599129559.
- Nociceptin depiction Nociceptin.png.
- Nociceptin isPrimaryTopicOf Nociceptin.
