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- Nomifensine abstract "Nomifensine (Merital, Alival) is a norepinephrine-dopamine reuptake inhibitor developed by a team at Hoechst AG in the 1960s. The drug was test marketed in the United States by Hoechst AG (now Sanofi-Aventis), i.e. a drug that increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters. This is a mechanism of action shared by some recreational drugs like cocaine (see DRI).Nomifensine was investigated for use as an antidepressant in the 1970s, and was found to be a useful antidepressant at doses of 50–225 mg per day, both motivating and anxiolytic. There were relatively few adverse effects (mainly dry mouth, headache, nausea), the drug was not sedating, did not interact significantly with alcohol and lacked anticholinergic effects. No withdrawal symptoms were seen after 6 months treatment. The drug was however considered not suitable for agitated patients as it presumably made agitation worse.Some case reports in the 1980s suggested that there was potential for psychological dependence on nomifensine, typically in patients with a history of stimulant addiction, or when the drug was used in very high doses (400–600 mg per day).In a 1989 study it has been investigated for use in treating adult ADHD and proven successful. In a 1977 study it has not proven of benefit in advanced parkinsonism, except for depression associated with the parkinsonism.Due to the risk of a risk of haemolytic anaemia, the U.S. Food and Drug Administration (FDA) withdrew approval for nomifensine on March 20, 1992. Nomifensine has subsequently been withdrawn from the Canadian and UK markets as well.Some deaths were linked to immunohaemolytic anemia caused by this compound although the mechanism remained unclear.In 2012 structure–affinity relationship data (compare SAR) were published.".
- Nomifensine atcPrefix "N06".
- Nomifensine atcSuffix "AX04".
- Nomifensine casNumber "24526-64-5".
- Nomifensine chEBI "116225".
- Nomifensine drugbank "DB04821".
- Nomifensine fdaUniiCode "1LGS5JRP31".
- Nomifensine iupacName "(±)-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine".
- Nomifensine pubchem "4528".
- Nomifensine thumbnail Nomifensine2D.svg?width=300.
- Nomifensine wikiPageID "3281168".
- Nomifensine wikiPageRevisionID "589006214".
- Nomifensine atcPrefix "N06".
- Nomifensine atcSuffix "AX04".
- Nomifensine c "16".
- Nomifensine casNumber "24526".
- Nomifensine chebi "116225".
- Nomifensine chembl "273575".
- Nomifensine chemspiderid "4371".
- Nomifensine drugbank "DB04821".
- Nomifensine eliminationHalfLife "-14400.0".
- Nomifensine h "18".
- Nomifensine hasPhotoCollection Nomifensine.
- Nomifensine image "Nomifensine3Dan.gif".
- Nomifensine inchi "1".
- Nomifensine inchikey "XXPANQJNYNUNES-UHFFFAOYAL".
- Nomifensine iupacName "-2".
- Nomifensine legalStatus "Rx-only".
- Nomifensine molecularWeight "238.328".
- Nomifensine n "2".
- Nomifensine pubchem "4528".
- Nomifensine routesOfAdministration "Oral".
- Nomifensine smiles "NC1=CC2=CC=C1".
- Nomifensine stdinchi "1".
- Nomifensine stdinchikey "XXPANQJNYNUNES-UHFFFAOYSA-N".
- Nomifensine unii "1".
- Nomifensine verifiedfields "changed".
- Nomifensine verifiedrevid "462262394".
- Nomifensine watchedfields "changed".
- Nomifensine width "150".
- Nomifensine width "250".
- Nomifensine subject Category:Anilines.
- Nomifensine subject Category:Norepinephrine-dopamine_reuptake_inhibitors.
- Nomifensine subject Category:Tetrahydroisoquinolines.
- Nomifensine subject Category:Withdrawn_drugs.
- Nomifensine type Agent114778436.
- Nomifensine type CausalAgent100007347.
- Nomifensine type Drug103247620.
- Nomifensine type Inhibitor114724436.
- Nomifensine type Matter100020827.
- Nomifensine type Norepinephrine-dopamineReuptakeInhibitors.
- Nomifensine type PhysicalEntity100001930.
- Nomifensine type Substance100020090.
- Nomifensine type WithdrawnDrugs.
- Nomifensine type Drug.
- Nomifensine type DrugProduct.
- Nomifensine type FunctionalSubstance.
- Nomifensine comment "Nomifensine (Merital, Alival) is a norepinephrine-dopamine reuptake inhibitor developed by a team at Hoechst AG in the 1960s. The drug was test marketed in the United States by Hoechst AG (now Sanofi-Aventis), i.e. a drug that increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.".
- Nomifensine label "Nomifensin".
- Nomifensine label "Nomifensina".
- Nomifensine label "Nomifensine".
- Nomifensine label "Номифензин".
- Nomifensine sameAs Nomifensin.
- Nomifensine sameAs Nomifensina.
- Nomifensine sameAs m.0932lr.
- Nomifensine sameAs Q409948.
- Nomifensine sameAs Q409948.
- Nomifensine sameAs DB04821.
- Nomifensine sameAs Nomifensine.
- Nomifensine wasDerivedFrom Nomifensine?oldid=589006214.
- Nomifensine depiction Nomifensine2D.svg.
- Nomifensine isPrimaryTopicOf Nomifensine.
