Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Notch_3> ?p ?o. }
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- Notch_3 abstract "Neurogenic locus notch homolog protein 3 is a protein that in humans is encoded by the NOTCH3 gene.This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined.== Pathology ==Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Mutations in NOTCH3 have also been identified in a Turkish family with Alzheimer's disease.".
- Notch_3 entrezgene "4854".
- Notch_3 thumbnail CADASIL_-_very_high_mag.jpg?width=300.
- Notch_3 wikiPageID "10739571".
- Notch_3 wikiPageRevisionID "593549322".
- Notch_3 hasPhotoCollection Notch_3.
- Notch_3 requireManualInspection "no".
- Notch_3 summaryText "This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Pathology thumb|Micrograph showing CADASIL with a Notch 3 immunostain. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy . Mutations in NOTCH3 have also been identified in a Turkish family with Alzheimer's disease.".
- Notch_3 updateCitations "yes".
- Notch_3 updatePage "yes".
- Notch_3 updateProteinBox "yes".
- Notch_3 updateSummary "no".
- Notch_3 type Biomolecule.
- Notch_3 type Protein.
- Notch_3 type BiologicalObject.
- Notch_3 comment "Neurogenic locus notch homolog protein 3 is a protein that in humans is encoded by the NOTCH3 gene.This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development.".
- Notch_3 label "NOTCH3".
- Notch_3 label "Notch 3".
- Notch_3 sameAs NOTCH3.
- Notch_3 sameAs m.02qnrj5.
- Notch_3 sameAs Q7062526.
- Notch_3 sameAs Q7062526.
- Notch_3 sameAs NOTCH3.
- Notch_3 wasDerivedFrom Notch_3?oldid=593549322.
- Notch_3 depiction CADASIL_-_very_high_mag.jpg.
- Notch_3 isPrimaryTopicOf Notch_3.
