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- Notch_proteins abstract "Notch (DSL) proteins are a family of transmembrane proteins with repeated extracellular EGF domains and the notch (or DSL) domains. These proteins are involved in lateral inhibition in embryogenesis.The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.".
- Notch_proteins symbol "Notch".
- Notch_proteins thumbnail PDB_1pb5_EBI.jpg?width=300.
- Notch_proteins wikiPageID "24009708".
- Notch_proteins wikiPageRevisionID "604888257".
- Notch_proteins caption "Structure of a Prototype LNR Module from Human Notch1.".
- Notch_proteins hasPhotoCollection Notch_proteins.
- Notch_proteins interpro "IPR000800".
- Notch_proteins name "Notch domain".
- Notch_proteins pdb "A:1447-1481".
- Notch_proteins pfam "PF00066".
- Notch_proteins prosite "PS50258".
- Notch_proteins smart "SM00004".
- Notch_proteins summaryText "This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.".
- Notch_proteins symbol "Notch".
- Notch_proteins subject Category:Protein_domains.
- Notch_proteins subject Category:Protein_families.
- Notch_proteins subject Category:Single-pass_transmembrane_proteins.
- Notch_proteins type Abstraction100002137.
- Notch_proteins type Attribute100024264.
- Notch_proteins type Chemical114806838.
- Notch_proteins type Compound114818238.
- Notch_proteins type Environment113934596.
- Notch_proteins type Macromolecule114944888.
- Notch_proteins type Material114580897.
- Notch_proteins type Matter100020827.
- Notch_proteins type Molecule114682133.
- Notch_proteins type OrganicCompound114727670.
- Notch_proteins type Part113809207.
- Notch_proteins type PhysicalEntity100001930.
- Notch_proteins type Protein114728724.
- Notch_proteins type ProteinDomains.
- Notch_proteins type Relation100031921.
- Notch_proteins type Single-passTransmembraneProteins.
- Notch_proteins type Situation113927383.
- Notch_proteins type Sphere114514039.
- Notch_proteins type State100024720.
- Notch_proteins type Substance100019613.
- Notch_proteins type Thing100002452.
- Notch_proteins type Unit109465459.
- Notch_proteins type Biomolecule.
- Notch_proteins type Protein.
- Notch_proteins type BiologicalObject.
- Notch_proteins comment "Notch (DSL) proteins are a family of transmembrane proteins with repeated extracellular EGF domains and the notch (or DSL) domains. These proteins are involved in lateral inhibition in embryogenesis.The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells.".
- Notch_proteins label "Notch proteins".
- Notch_proteins label "Notch".
- Notch_proteins sameAs m.07k5tp7.
- Notch_proteins sameAs Q4045508.
- Notch_proteins sameAs Q4045508.
- Notch_proteins sameAs Notch_proteins.
- Notch_proteins wasDerivedFrom Notch_proteins?oldid=604888257.
- Notch_proteins depiction PDB_1pb5_EBI.jpg.
- Notch_proteins isPrimaryTopicOf Notch_proteins.
