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• Nuclear_pore abstract "Nuclear pores are large protein complexes that cross the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus. There are about an average of 2000 nuclear pore complexes (NPCs), in the nuclear envelope of a vertebrate cell, but it varies depending on cell type and the stage in the life cycle. The proteins that make up the nuclear pore complex are known as nucleoporins. About half of the nucleoporins typically contain solenoid protein domains—either an alpha solenoid or a beta-propeller fold, or in some cases both as separate structural domains. Each NPC contains at least 456 individual protein molecules and is composed of 30 distinct proteins (nucleoporins). The other half show structural characteristics typical of "natively unfolded" or intrinsically disordered proteins, i.e. they are highly flexible proteins that lack ordered secondary structure. These disordered proteins are the FG nucleoporins, so called because their amino-acid sequence contains many repeats of the peptide phenylalanine—glycine.Nuclear pore complexes allow the transport of molecules across the nuclear envelope. This transport includes RNA and ribosomal proteins moving from nucleus to the cytoplasm and proteins (such as DNA polymerase and lamins), carbohydrates, signaling molecules and lipids moving into the nucleus. It is notable that the nuclear pore complex (NPC) can actively conduct 1000 translocations per complex per second. Although smaller molecules simply diffuse through the pores, larger molecules may be recognized by specific signal sequences and then be diffused with the help of nucleoporins into or out of the nucleus. This is not directly energy requiring, but depends on concentrations gradients associated with the RAN cycle. Each of the eight protein subunits surrounding the actual pore (the outer ring) projects a spoke-shaped protein over the pore channel. The center of the pore often appears to contain a plug-like structure. It is yet unknown whether this corresponds to an actual plug or is merely cargo caught in transit.".
• Nuclear_pore thumbnail Diagram_human_cell_nucleus.svg?width=300.
• Nuclear_pore wikiPageExternalLink nuclearporecomplex.
• Nuclear_pore wikiPageExternalLink nuclearporecomplex2.
• Nuclear_pore wikiPageExternalLink NCDIR%20-%20National%20Center%20for%20the%20Dynamic%20Interactome.
• Nuclear_pore wikiPageExternalLink nuclear%20pore.
• Nuclear_pore wikiPageID "21957".
• Nuclear_pore wikiPageRevisionID "602174853".
• Nuclear_pore hasPhotoCollection Nuclear_pore.
• Nuclear_pore subject Category:Cell_anatomy.
• Nuclear_pore subject Category:Membrane_biology.
• Nuclear_pore subject Category:Nuclear_substructures.
• Nuclear_pore type Abstraction100002137.
• Nuclear_pore type Attribute100024264.
• Nuclear_pore type Constitution104933544.
• Nuclear_pore type Infrastructure103570372.
• Nuclear_pore type NuclearSubstructures.
• Nuclear_pore type Property104916342.
• Nuclear_pore type Structure104931965.
• Nuclear_pore comment "Nuclear pores are large protein complexes that cross the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus. There are about an average of 2000 nuclear pore complexes (NPCs), in the nuclear envelope of a vertebrate cell, but it varies depending on cell type and the stage in the life cycle. The proteins that make up the nuclear pore complex are known as nucleoporins.".
• Nuclear_pore label "Kernpore".
• Nuclear_pore label "Kernporie".
• Nuclear_pore label "Nuclear pore".
• Nuclear_pore label "Por jądrowy".
• Nuclear_pore label "Pore nucléaire".
• Nuclear_pore label "Poro nuclear".
• Nuclear_pore label "Poro nuclear".
• Nuclear_pore label "Poro nucleare".
• Nuclear_pore label "Ядерные поры".
• Nuclear_pore label "核孔".
• Nuclear_pore label "核膜孔".
• Nuclear_pore sameAs Jaderný_pór.
• Nuclear_pore sameAs Kernpore.
• Nuclear_pore sameAs Poro_nuclear.
• Nuclear_pore sameAs Poro_nuklear.
• Nuclear_pore sameAs Pore_nucléaire.
• Nuclear_pore sameAs Poro_nucleare.
• Nuclear_pore sameAs 核膜孔.
• Nuclear_pore sameAs 핵공.
• Nuclear_pore sameAs Kernporie.
• Nuclear_pore sameAs Por_jądrowy.
• Nuclear_pore sameAs Poro_nuclear.
• Nuclear_pore sameAs m.05hzd.
• Nuclear_pore sameAs Q30679.
• Nuclear_pore sameAs Q30679.
• Nuclear_pore sameAs Nuclear_pore.
• Nuclear_pore wasDerivedFrom Nuclear_pore?oldid=602174853.
• Nuclear_pore depiction Diagram_human_cell_nucleus.svg.
• Nuclear_pore isPrimaryTopicOf Nuclear_pore.