Matches in DBpedia 2014 for { <http://dbpedia.org/resource/OAS1> ?p ?o. }
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- OAS1 abstract "2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.".
- OAS1 entrezgene "4938".
- OAS1 wikiPageID "14166840".
- OAS1 wikiPageRevisionID "592685021".
- OAS1 hasPhotoCollection OAS1.
- OAS1 requireManualInspection "no".
- OAS1 summaryText "This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates . These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.".
- OAS1 updateCitations "yes".
- OAS1 updatePage "yes".
- OAS1 updateProteinBox "yes".
- OAS1 updateSummary "yes".
- OAS1 type Biomolecule.
- OAS1 type Protein.
- OAS1 type BiologicalObject.
- OAS1 comment "2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As).".
- OAS1 label "OAS1".
- OAS1 sameAs m.03cwn9m.
- OAS1 sameAs Q7072289.
- OAS1 sameAs Q7072289.
- OAS1 sameAs OAS1.
- OAS1 sameAs 4898.
- OAS1 wasDerivedFrom OAS1?oldid=592685021.
- OAS1 isPrimaryTopicOf OAS1.