Matches in DBpedia 2014 for { <http://dbpedia.org/resource/ORAI1> ?p ?o. }
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- ORAI1 abstract "Calcium release-activated calcium channel protein 1 is a calcium selective ion channel that in humans is encoded by the ORAI1 gene. Orai1 channels play an important role in the activation of T-lymphocytes. The loss of function mutation of Orai1 causes severe combined immunodeficiency (SCID) in humans The mammalian orai family has two additional homologs, orai2 and orai3. Orai proteins share no homology with any other ion channel family of any other known proteins. They have 4 transmembrane domains and form tetramers. Orai channels are activated upon the depletion of internal calcium stores, which is called the "store-operated" or the "capacitative" mechanism. They are molecular constituents of the "calcium release activated calcium currents" (ICRAC). Upon activation of phospholipase C by various cell surface receptors, inositol trisphosphate is formed that releases calcium from the endoplasmic reticulum. The decreased calcium concentration in the endoplasmic reticulum is sensed by the STIM1 protein. STIM1 clusters upon the depletion of the calcium stores and forms "puncta", and relocates near the plasma membrane, where it activates orai1 via protein protein interaction.".
- ORAI1 entrezgene "84876".
- ORAI1 wikiPageID "14035282".
- ORAI1 wikiPageRevisionID "592713486".
- ORAI1 hasPhotoCollection ORAI1.
- ORAI1 requireManualInspection "no".
- ORAI1 updateCitations "yes".
- ORAI1 updatePage "yes".
- ORAI1 updateProteinBox "yes".
- ORAI1 updateSummary "yes".
- ORAI1 type Biomolecule.
- ORAI1 type Protein.
- ORAI1 type BiologicalObject.
- ORAI1 comment "Calcium release-activated calcium channel protein 1 is a calcium selective ion channel that in humans is encoded by the ORAI1 gene. Orai1 channels play an important role in the activation of T-lymphocytes. The loss of function mutation of Orai1 causes severe combined immunodeficiency (SCID) in humans The mammalian orai family has two additional homologs, orai2 and orai3. Orai proteins share no homology with any other ion channel family of any other known proteins.".
- ORAI1 label "ORAI1".
- ORAI1 sameAs m.03cpzp0.
- ORAI1 sameAs Q7072901.
- ORAI1 sameAs Q7072901.
- ORAI1 wasDerivedFrom ORAI1?oldid=592713486.
- ORAI1 isPrimaryTopicOf ORAI1.