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- ob_mouse abstract "The ob/ob or obese mouse is a mutant mouse that eats excessively and becomes profoundly obese. It is an animal model of type II diabetes. Identification of the gene mutated in ob led to the discovery of the hormone leptin, which is important in the control of appetite.The first ob/ob mouse arose by chance in a colony at the Jackson Laboratory in 1949. The mutation is recessive. Mutant mice are phenotypically indistinguishable from their unaffected littermates at birth, but gain weight rapidly throughout their lives, reaching a weight three times that of unaffected mice. ob/ob mice develop high blood sugar, despite an enlargement of the pancreatic islets and increased levels of insulin.The gene affected by the ob mutation was identified by positional cloning. The gene produces a hormone, called leptin, that is produced predominantly in adipose tissue. One role of leptin is to regulate appetite by signalling to the brain that the animal has had enough to eat. Since the ob/ob mouse cannot produce leptin, its food intake is uncontrolled by this mechanism.".
- ob_mouse thumbnail Fatmouse.jpg?width=300.
- ob_mouse wikiPageExternalLink 41-317.pdf.
- ob_mouse wikiPageID "15311476".
- ob_mouse wikiPageRevisionID "592685377".
- ob_mouse hasPhotoCollection ob_mouse.
- ob_mouse subject Category:Classical_genetics.
- ob_mouse subject Category:Laboratory_mouse_breeds.
- ob_mouse type Animal100015388.
- ob_mouse type Chordate101466257.
- ob_mouse type LivingThing100004258.
- ob_mouse type Mammal101861778.
- ob_mouse type Mice.
- ob_mouse type ModelOrganisms.
- ob_mouse type Mouse102330245.
- ob_mouse type Object100002684.
- ob_mouse type Organism100004475.
- ob_mouse type PhysicalEntity100001930.
- ob_mouse type Placental101886756.
- ob_mouse type Rodent102329401.
- ob_mouse type Vertebrate101471682.
- ob_mouse type Whole100003553.
- ob_mouse comment "The ob/ob or obese mouse is a mutant mouse that eats excessively and becomes profoundly obese. It is an animal model of type II diabetes. Identification of the gene mutated in ob led to the discovery of the hormone leptin, which is important in the control of appetite.The first ob/ob mouse arose by chance in a colony at the Jackson Laboratory in 1949. The mutation is recessive.".
- ob_mouse label "Ob/ob mouse".
- ob_mouse sameAs m.03m4hz0.
- ob_mouse sameAs Q7074528.
- ob_mouse sameAs Q7074528.
- ob_mouse sameAs ob_mouse.
- ob_mouse wasDerivedFrom ob_mouse?oldid=592685377.
- ob_mouse depiction Fatmouse.jpg.
- ob_mouse isPrimaryTopicOf ob_mouse.
