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- Omecamtiv_mecarbil abstract "Omecamtiv mecarbil (INN), previously codenamed CK-1827452, is a cardiac specific myosin activator. It is clinically tested for its role in the treatment of left ventricular systolic heart failure. Systolic heart failure is characterised as a decreased cardiac output (<40% ejection fraction), due to decreased stroke volume, resulting in the inability to meet the metabolic demands of the body. The loss of contraction is caused by a reduced number of effective actin-myosin cross bridges in the left ventricular myocytes. One possible underlying mechanism is altered signal transduction that interferes with excitation-contraction coupling. A decreased cardiac output causes peripheral hypotension and activation of the sympathetic nervous system. This in turn stimulates the cardiac myocytes excessively, eventually leading to left ventricular hypertrophy, characteristic of chronic heart failure. Some symptoms of systolic heart failure are fatigue, peripheral oedema, dyspnoea, exercise intolerance and breathlessness. Current inotropic drug therapies such as dobutamine, are palliative and not a cure. They also cause many adverse effects including arrhythmias related to increased myocardical oxygen consumption, desensitization of adrenergic receptors and altering intracellular calcium levels. Thus systolic heart failure is considered malignant, however the novel mechanism of Omecamtiv Mecarbil is a hopeful long-term resolution.".
- Omecamtiv_mecarbil atcPrefix "None".
- Omecamtiv_mecarbil casNumber "873697-71-3".
- Omecamtiv_mecarbil iupacName "Methyl 4-[(2-fluoro-3-{[N-(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate".
- Omecamtiv_mecarbil pubchem "11689883".
- Omecamtiv_mecarbil thumbnail Omecamtiv_mecarbil.svg?width=300.
- Omecamtiv_mecarbil wikiPageID "31273493".
- Omecamtiv_mecarbil wikiPageRevisionID "601847094".
- Omecamtiv_mecarbil atcPrefix "None".
- Omecamtiv_mecarbil c "20".
- Omecamtiv_mecarbil casNumber "873697".
- Omecamtiv_mecarbil chemspiderid "9864610".
- Omecamtiv_mecarbil drugName "Omecamtiv mecarbil".
- Omecamtiv_mecarbil f "1".
- Omecamtiv_mecarbil h "24".
- Omecamtiv_mecarbil hasPhotoCollection Omecamtiv_mecarbil.
- Omecamtiv_mecarbil iupacName "Methyl 4-[methyl]piperazine-1-carboxylate".
- Omecamtiv_mecarbil legalStatus "Investigational".
- Omecamtiv_mecarbil molecularWeight "401.43".
- Omecamtiv_mecarbil n "5".
- Omecamtiv_mecarbil o "3".
- Omecamtiv_mecarbil pubchem "11689883".
- Omecamtiv_mecarbil routesOfAdministration Intravenous_therapy.
- Omecamtiv_mecarbil smiles "O=CNc2ccCN3CCNCC3".
- Omecamtiv_mecarbil stdinchi "1".
- Omecamtiv_mecarbil stdinchikey "RFUBTTPMWSKEIW-UHFFFAOYSA-N".
- Omecamtiv_mecarbil synonyms "CK-1827452".
- Omecamtiv_mecarbil subject Category:Drugs_acting_on_the_cardiovascular_system.
- Omecamtiv_mecarbil type Drug.
- Omecamtiv_mecarbil type FunctionalSubstance.
- Omecamtiv_mecarbil comment "Omecamtiv mecarbil (INN), previously codenamed CK-1827452, is a cardiac specific myosin activator. It is clinically tested for its role in the treatment of left ventricular systolic heart failure. Systolic heart failure is characterised as a decreased cardiac output (<40% ejection fraction), due to decreased stroke volume, resulting in the inability to meet the metabolic demands of the body.".
- Omecamtiv_mecarbil label "Omecamtiv mecarbil".
- Omecamtiv_mecarbil sameAs m.0gj9x0j.
- Omecamtiv_mecarbil sameAs Q7089956.
- Omecamtiv_mecarbil sameAs Q7089956.
- Omecamtiv_mecarbil wasDerivedFrom Omecamtiv_mecarbil?oldid=601847094.
- Omecamtiv_mecarbil depiction Omecamtiv_mecarbil.svg.
- Omecamtiv_mecarbil isPrimaryTopicOf Omecamtiv_mecarbil.
- Omecamtiv_mecarbil name "Omecamtiv mecarbil".
