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- Oncotype_DX abstract "Oncotype DX, developed by Genomic Health, is a diagnostic test that quantifies the likelihood of disease recurrence in women with early-stage hormone estrogen receptor (ER) positive only breast cancer (prognostic significance) and assesses the likely benefit from certain types of chemotherapy (predictive significance).Oncotype DX analyzes a panel of 21 genes within a tumor to determine a Recurrence Score. The Recurrence Score is a number between 0 and 100 that corresponds to a specific likelihood of breast cancer recurrence within 10 years of the initial diagnosis, though the score is not validated, though the buckets of Low, Intermediate or High Risk are when the patient receives / abides to 5 years of Tamoxifen. With this information, it may be possible for doctors and patients to make more informed decisions about breast cancer treatment options. Oncotype DX is performed by Genomic Health in its CLIA-certified, CAP-accredited reference laboratory.Oncotype DX was initially developed for women with early-stage invasive breast cancer with ER+ cancers whose lymph nodes do not contain tumor (node-negative). Typically in these cases, treatment with anti-hormonal therapy, such as tamoxifen or aromatase inhibitors, is planned, and the test can help define whether chemotherapy should or should not be added to that anti-hormone treatment. Oncotype DX remains unproven for use in patients with carcinoma in situ (precancerous) or distant metastatic breast cancer. However, in an analysis of tissue samples from a large clinical trial (SWOG 8814), Oncotype DX demonstrated both prognostic significance (the capability of predicting distant recurrence) and predictive significance ( a second and different characteristic that describes the capability of the test to assess the potential benefit of additional adjuvant chemotherapy) in women with estrogen receptor positive early breast cancer whose lymph nodes show spread of their tumor (node-positive), and the test has also shown similar prognostic and predictive significance in women both either node negative or node positive early breast cancer who received adjuvant treatment with the aromatase inhibitor anastrozole. Moreover, small studies with tumor specimens from breast cancer patients receiving neoadjuvant treatment show similar results and suggest that the test may predict response to neoadjuvant hormonal therapy (oncology) and chemotherapy.Oncotype DX is a noninvasive test that is performed on a small amount of the tissue removed during the original surgery lumpectomy, mastectomy, or core biopsy, which means no additional invasive procedure is required. After the surgical procedure, the tissue sample is fixed in formalin and embedded in paraffin so it can be preserved for further diagnostic testing.To perform Oncotype DX, the pathologist will send several thin sections of the formalin-fixed, paraffin-embedded tissue sample to Genomic Health. Oncotype DX uses a highly reproducible laboratory process known as RT-PCR to determine the expression of the 21-gene panel. The Oncotype DX test results are then integrated with other laboratory test results to help doctors formulate a treatment plan based on the unique characteristics of the tumor. Since Oncotype DX became available in 2004, it has been used by over 10,000 physicians to help guide treatment for over 200,000 patients in 60+ countries.".
- Oncotype_DX wikiPageExternalLink www.genomichealth.com.
- Oncotype_DX wikiPageExternalLink IsOncotypeRight.aspx.
- Oncotype_DX wikiPageExternalLink Breast.aspx.
- Oncotype_DX wikiPageExternalLink IsOncotypeRight.aspx.
- Oncotype_DX wikiPageID "7734197".
- Oncotype_DX wikiPageRevisionID "592702352".
- Oncotype_DX hasPhotoCollection Oncotype_DX.
- Oncotype_DX subject Category:Medical_tests.
- Oncotype_DX subject Category:Oncology.
- Oncotype_DX type Abstraction100002137.
- Oncotype_DX type Cognition100023271.
- Oncotype_DX type Experiment105798043.
- Oncotype_DX type HigherCognitiveProcess105770664.
- Oncotype_DX type Inquiry105797597.
- Oncotype_DX type MedicalTests.
- Oncotype_DX type ProblemSolving105796750.
- Oncotype_DX type Process105701363.
- Oncotype_DX type PsychologicalFeature100023100.
- Oncotype_DX type Thinking105770926.
- Oncotype_DX type Trial105799212.
- Oncotype_DX comment "Oncotype DX, developed by Genomic Health, is a diagnostic test that quantifies the likelihood of disease recurrence in women with early-stage hormone estrogen receptor (ER) positive only breast cancer (prognostic significance) and assesses the likely benefit from certain types of chemotherapy (predictive significance).Oncotype DX analyzes a panel of 21 genes within a tumor to determine a Recurrence Score.".
- Oncotype_DX label "Oncotype DX".
- Oncotype_DX label "Oncotype DX".
- Oncotype_DX label "Oncotype DX".
- Oncotype_DX sameAs Oncotype_DX.
- Oncotype_DX sameAs Oncotype_DX.
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- Oncotype_DX sameAs Q1739962.
- Oncotype_DX sameAs Q1739962.
- Oncotype_DX sameAs Oncotype_DX.
- Oncotype_DX wasDerivedFrom Oncotype_DX?oldid=592702352.
- Oncotype_DX homepage Breast.aspx.
- Oncotype_DX isPrimaryTopicOf Oncotype_DX.