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- Origin_recognition_complex abstract "In molecular biology, ORC or origin recognition complex is a multi-subunit DNA binding complex (6 subunits) that binds in all eukaryotes in an ATP-dependent manner to origins of replication. The subunits of this complex are encoded by the ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6 genes. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle. ORC directs DNA replication throughout the genome and is required for its initiation. ORC bound at replication origins serves as the foundation for assembly of the pre-replication complex (pre-RC), which includes Cdc6, Tah11 (aka Cdt1), and the Mcm2-Mcm7 complex. Pre-RC assembly during G1 is required for replication licensing of chromosomes prior to DNA synthesis during S phase. Cell cycle-regulated phosphorylation of Orc2, Orc6, Cdc6, and MCM by the cyclin-dependent protein kinase Cdc28 regulates initiation of DNA replication, including blocking reinitiation in G2/M phase.In yeast, ORC also plays a role in the establishment of silencing at the mating-type loci Hidden MAT Left (HML) and Hidden MAT Right (HMR). ORC participates in the assembly of transcriptionally silent chromatin at HML and HMR by recruiting the Sir1 silencing protein to the HML and HMR silencers.Both Orc1 and Orc5 bind ATP, though only Orc1 has ATPase activity. The binding of ATP by Orc1 is required for ORC binding to DNA and is essential for cell viability. The ATPase activity of Orc1 is involved in formation of the pre-RC. ATP binding by Orc5 is crucial for the stability of ORC as a whole. Only the Orc1-5 subunits are required for origin binding; Orc6 is essential for maintenance of pre-RCs once formed. Interactions within ORC suggest that Orc2-3-6 may form a core complex.".
- Origin_recognition_complex symbol "ORC2".
- Origin_recognition_complex symbol "ORC3_N".
- Origin_recognition_complex symbol "ORC6".
- Origin_recognition_complex thumbnail CDC6_Function.jpg?width=300.
- Origin_recognition_complex wikiPageID "7428170".
- Origin_recognition_complex wikiPageRevisionID "592718138".
- Origin_recognition_complex hasPhotoCollection Origin_recognition_complex.
- Origin_recognition_complex interpro "IPR007220".
- Origin_recognition_complex interpro "IPR008721".
- Origin_recognition_complex interpro "IPR010748".
- Origin_recognition_complex name "Origin recognition complex subunit 3 N-terminus".
- Origin_recognition_complex name "Origin recognition complex subunit 2".
- Origin_recognition_complex name "Origin recognition complex subunit 6".
- Origin_recognition_complex pfam "PF04084".
- Origin_recognition_complex pfam "PF05460".
- Origin_recognition_complex pfam "PF07034".
- Origin_recognition_complex symbol "ORC2".
- Origin_recognition_complex symbol "ORC3_N".
- Origin_recognition_complex symbol "ORC6".
- Origin_recognition_complex subject Category:DNA.
- Origin_recognition_complex subject Category:Eukaryotes.
- Origin_recognition_complex subject Category:Protein_families.
- Origin_recognition_complex type Abstraction100002137.
- Origin_recognition_complex type Family108078020.
- Origin_recognition_complex type Group100031264.
- Origin_recognition_complex type Organization108008335.
- Origin_recognition_complex type ProteinFamilies.
- Origin_recognition_complex type SocialGroup107950920.
- Origin_recognition_complex type Unit108189659.
- Origin_recognition_complex type YagoLegalActor.
- Origin_recognition_complex type YagoLegalActorGeo.
- Origin_recognition_complex type YagoPermanentlyLocatedEntity.
- Origin_recognition_complex type Biomolecule.
- Origin_recognition_complex type Protein.
- Origin_recognition_complex type BiologicalObject.
- Origin_recognition_complex comment "In molecular biology, ORC or origin recognition complex is a multi-subunit DNA binding complex (6 subunits) that binds in all eukaryotes in an ATP-dependent manner to origins of replication. The subunits of this complex are encoded by the ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6 genes. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle. ORC directs DNA replication throughout the genome and is required for its initiation.".
- Origin_recognition_complex label "Complejo de reconocimiento de origen".
- Origin_recognition_complex label "Origin Recognition Complex".
- Origin_recognition_complex label "Origin recognition complex".
- Origin_recognition_complex sameAs Complejo_de_reconocimiento_de_origen.
- Origin_recognition_complex sameAs Origin_Recognition_Complex.
- Origin_recognition_complex sameAs m.02619x3.
- Origin_recognition_complex sameAs Q1626856.
- Origin_recognition_complex sameAs Q1626856.
- Origin_recognition_complex sameAs Origin_recognition_complex.
- Origin_recognition_complex wasDerivedFrom Origin_recognition_complex?oldid=592718138.
- Origin_recognition_complex depiction CDC6_Function.jpg.
- Origin_recognition_complex isPrimaryTopicOf Origin_recognition_complex.
