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- Orphenadrine abstract "Orphenadrine (sold under the brand names: Norflex, Mephenamin, Disipal, Banflex, Flexon, Biorphen, Brocasipal, Dolan, Norgesic, OrfenAce and others) is an anticholinergic drug of the ethanolamine antihistamine class with prominent CNS and peripheral actions used to treat painful muscle spasms, other similar conditions, as well as the treatment of some aspects of Parkinson's Disease. It is closely related to diphenhydramine. Therefore, it is related to other drugs used for Parkinson's like benztropine and trihexyphenidyl, and it is also structurally related to nefopam, which is a centrally-acting yet non-opioid analgesic. The combination of anticholinergic effects and CNS penetration make orphenadrine useful for pain of all etiologies, including pain from: radiculopathy, muscle pain, and headaches[citation needed]. Orphenadrine has approximately 58% of the anticholinergic potency of atropine at equivalent doses.Orphenadrine is most often used against pain and muscle spasm of various etiologies including lumbago, sciatica, and injury. It is quite useful against allergic symptoms and other histamine-related effects, such as those from hay fever, other allergies, and histamine release from many opioid analgesics. Where available for prescription compounding, orphenadrine can also be prepared for topical administration and works slightly better than diphenhydramine for this purpose.The orphenadrine salt used for Parkinsonism is the hydrochloride, whereas the muscle relaxant tablets are the citrate. The manufacturers' descriptions of orphenadrine indicate that the salts are not interchangeable; one reason may be that the citrate can be irritating when injected.Euphoria is an effect reported by many patients and orphenadrine has been investigated for use against depression, as first reported in June 1958 in the American Journal of Psychiatry.Like many first-generation antihistamines and chemically-similar anticholinergics, orphenadrine can also cause excitement and insomnia, particularly in children and the elderly.Orphenadrine also works on smooth muscle in a manner identical to that of dicyclomine, brand name Bentyl, and will impact Irritable Bowel Syndrome in a similar fashion.".
- Orphenadrine atcPrefix "M03".
- Orphenadrine atcSuffix "BC01".
- Orphenadrine bioavailability "90.0".
- Orphenadrine casNumber "83-98-7".
- Orphenadrine chEBI "7789".
- Orphenadrine drugbank "DB01173".
- Orphenadrine fdaUniiCode "AL805O9OG9".
- Orphenadrine iupacName "N,N-dimethyl-2-[(2-methylphenyl)- phenyl-methoxy]-ethanamine".
- Orphenadrine pubchem "4601".
- Orphenadrine thumbnail Orphenadrine.svg?width=300.
- Orphenadrine wikiPageExternalLink summary.cgi?sid=270956.
- Orphenadrine wikiPageExternalLink md30554.jpg.
- Orphenadrine wikiPageID "1983341".
- Orphenadrine wikiPageRevisionID "602694941".
- Orphenadrine atcPrefix "M03".
- Orphenadrine atcSuffix "BC01".
- Orphenadrine bioavailability "90.0".
- Orphenadrine c "18".
- Orphenadrine casNumber "83".
- Orphenadrine chebi "7789".
- Orphenadrine chembl "900".
- Orphenadrine chemspiderid "4440".
- Orphenadrine drugbank "DB01173".
- Orphenadrine eliminationHalfLife "-72000.0".
- Orphenadrine excretion "Renal and biliary".
- Orphenadrine h "23".
- Orphenadrine hasPhotoCollection Orphenadrine.
- Orphenadrine inchi "1".
- Orphenadrine inchikey "QVYRGXJJSLMXQH-UHFFFAOYAX".
- Orphenadrine iupacName "N,N-dimethyl-2-[- phenyl-methoxy]-ethanamine".
- Orphenadrine kegg "D08305".
- Orphenadrine legalAu "S4".
- Orphenadrine legalCa "OTC".
- Orphenadrine legalUk "POM".
- Orphenadrine legalUs "Rx-only".
- Orphenadrine medlineplus "a682162".
- Orphenadrine metabolism Demethylation.
- Orphenadrine metabolism Liver.
- Orphenadrine molecularWeight "269.381".
- Orphenadrine n "1".
- Orphenadrine o "1".
- Orphenadrine pregnancyAu "B2".
- Orphenadrine pregnancyUs "C".
- Orphenadrine proteinBound "95.0".
- Orphenadrine pubchem "4601".
- Orphenadrine routesOfAdministration "Oral, intravenous, intramuscular".
- Orphenadrine smiles "OCc2ccccc2C".
- Orphenadrine stdinchi "1".
- Orphenadrine stdinchikey "QVYRGXJJSLMXQH-UHFFFAOYSA-N".
- Orphenadrine tradename "Invagesic".
- Orphenadrine unii "AL805O9OG9".
- Orphenadrine verifiedrevid "462265971".
- Orphenadrine subject Category:Amines.
- Orphenadrine subject Category:Ethers.
- Orphenadrine subject Category:H1_receptor_antagonists.
- Orphenadrine subject Category:Muscarinic_antagonists.
- Orphenadrine subject Category:Muscle_relaxants.
- Orphenadrine type Drug.
- Orphenadrine type DrugProduct.
- Orphenadrine type FunctionalSubstance.
- Orphenadrine comment "Orphenadrine (sold under the brand names: Norflex, Mephenamin, Disipal, Banflex, Flexon, Biorphen, Brocasipal, Dolan, Norgesic, OrfenAce and others) is an anticholinergic drug of the ethanolamine antihistamine class with prominent CNS and peripheral actions used to treat painful muscle spasms, other similar conditions, as well as the treatment of some aspects of Parkinson's Disease. It is closely related to diphenhydramine.".
- Orphenadrine label "Orfenadrina".
- Orphenadrine label "Orfenadrina".
- Orphenadrine label "Orphenadrine".
- Orphenadrine label "أورفينادرين".
- Orphenadrine sameAs Orfenadrina.
- Orphenadrine sameAs Orfenadrina.
- Orphenadrine sameAs m.06bvp4.
- Orphenadrine sameAs Q3292273.
- Orphenadrine sameAs Q3292273.
- Orphenadrine sameAs Orphenadrine.
- Orphenadrine sameAs DB01173.
- Orphenadrine sameAs 4601.
- Orphenadrine wasDerivedFrom Orphenadrine?oldid=602694941.
- Orphenadrine depiction Orphenadrine.svg.
- Orphenadrine isPrimaryTopicOf Orphenadrine.
