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- Orteronel abstract "Orteronel (TAK-700) is an experimental drug for the treatment of cancer discovered by Takeda Pharmaceutical Company and under development by Millennium Pharmaceuticals. It is currently in Phase III clinical trials for metastatic, hormone-refractory prostate cancer.Orteronel is an androgen synthesis inhibitor. It selectively inhibits the enzyme CYP17A1 which is expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17-α-hydroxy derivatives by its 17 α-hydroxylase activity, and (b) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by its C17,20 lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity thus decreases circulating levels of testosterone.".
- Orteronel iupacName "6-(7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methylnaphthalene-2-carboxamide".
- Orteronel thumbnail Orteronel.svg?width=300.
- Orteronel wikiPageID "32684479".
- Orteronel wikiPageRevisionID "598812426".
- Orteronel hasPhotoCollection Orteronel.
- Orteronel imagefile "Orteronel.svg".
- Orteronel imagesize "200".
- Orteronel iupacname "6".
- Orteronel othernames "TAK-700".
- Orteronel subject Category:Amides.
- Orteronel subject Category:Experimental_cancer_drugs.
- Orteronel subject Category:Naphthalenes.
- Orteronel type Abstraction100002137.
- Orteronel type Amide114724264.
- Orteronel type Amides.
- Orteronel type Chemical114806838.
- Orteronel type Compound114818238.
- Orteronel type Hydrocarbon114911057.
- Orteronel type Material114580897.
- Orteronel type Matter100020827.
- Orteronel type Naphthalene114958564.
- Orteronel type Naphthalenes.
- Orteronel type OrganicCompound114727670.
- Orteronel type Part113809207.
- Orteronel type PhysicalEntity100001930.
- Orteronel type Relation100031921.
- Orteronel type Substance100019613.
- Orteronel type ChemicalCompound.
- Orteronel type ChemicalSubstance.
- Orteronel type ChemicalObject.
- Orteronel type Thing.
- Orteronel comment "Orteronel (TAK-700) is an experimental drug for the treatment of cancer discovered by Takeda Pharmaceutical Company and under development by Millennium Pharmaceuticals. It is currently in Phase III clinical trials for metastatic, hormone-refractory prostate cancer.Orteronel is an androgen synthesis inhibitor. It selectively inhibits the enzyme CYP17A1 which is expressed in testicular, adrenal, and prostatic tumor tissues.".
- Orteronel label "Orteronel".
- Orteronel sameAs m.0h3x2ck.
- Orteronel sameAs Q6581305.
- Orteronel sameAs Q6581305.
- Orteronel sameAs Orteronel.
- Orteronel wasDerivedFrom Orteronel?oldid=598812426.
- Orteronel depiction Orteronel.svg.
- Orteronel isPrimaryTopicOf Orteronel.
