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- Ovariectomized_rat abstract "Currently there is no single animal model that identically represents the stages of osteoporosis in humans although there are some animals that are relatively close and can be used for the purpose of comparison. Both small animals and large animals are used depending on which aspects of the osteoporotic condition are being studied. Such animals include rats, rabbits, and sheep.Of these animal models, the ovariectomised (OVX) rat model remains the most popular choice as it has been validated to represent the most important clinical features of estrogen deficiency-induced (or postmenopausal) bone loss in the adult human, particularly during the early stages of osteoporosis. These include: increased rate of bone turnover with resorption exceeding formation; an initial rapid phase of bone loss followed by a much slower phase; greater loss of cancellous bone than cortical bone; reduced intestinal calcium absorption; some protection against bone loss by obesity; and similar skeletal response to therapy with estrogen, tamoxifen, bisphosphonates, parathyroid hormone, calcitonin and exercise.It also offers certain advantages compared the other animal models like rabbits and sheep. These include the ability to use peripheral micro-computed tomography (pQmicro-CT) in in vivo micro-CT to perform in vivo analyses, cost-effectiveness, and ease of handling and housing. Because of these considerations, the OVX rat model is widely used for the studies relating to the prevention and treatment of osteoporosis in general as well as studies relating to the healing of osteoporotic fractures.".
- Ovariectomized_rat wikiPageExternalLink index.htm.
- Ovariectomized_rat wikiPageExternalLink www.osteoporosis.org.au.
- Ovariectomized_rat wikiPageID "16776086".
- Ovariectomized_rat wikiPageRevisionID "594807640".
- Ovariectomized_rat hasPhotoCollection Ovariectomized_rat.
- Ovariectomized_rat subject Category:Model_organisms.
- Ovariectomized_rat type LivingThing100004258.
- Ovariectomized_rat type ModelOrganisms.
- Ovariectomized_rat type Object100002684.
- Ovariectomized_rat type Organism100004475.
- Ovariectomized_rat type PhysicalEntity100001930.
- Ovariectomized_rat type Whole100003553.
- Ovariectomized_rat comment "Currently there is no single animal model that identically represents the stages of osteoporosis in humans although there are some animals that are relatively close and can be used for the purpose of comparison. Both small animals and large animals are used depending on which aspects of the osteoporotic condition are being studied.".
- Ovariectomized_rat label "Ovariectomized rat".
- Ovariectomized_rat sameAs m.0405qv4.
- Ovariectomized_rat sameAs Q7113259.
- Ovariectomized_rat sameAs Q7113259.
- Ovariectomized_rat sameAs Ovariectomized_rat.
- Ovariectomized_rat wasDerivedFrom Ovariectomized_rat?oldid=594807640.
- Ovariectomized_rat isPrimaryTopicOf Ovariectomized_rat.