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- P4HB abstract "Protein disulfide-isomerase is an enzyme that in humans is encoded by the P4HB gene.This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.".
- P4HB entrezgene "5034".
- P4HB wikiPageExternalLink 6.
- P4HB wikiPageID "14723057".
- P4HB wikiPageRevisionID "597823399".
- P4HB hasPhotoCollection P4HB.
- P4HB requireManualInspection "no".
- P4HB summaryText "This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.".
- P4HB updateCitations "yes".
- P4HB updatePage "yes".
- P4HB updateProteinBox "yes".
- P4HB updateSummary "yes".
- P4HB type Biomolecule.
- P4HB type Protein.
- P4HB type BiologicalObject.
- P4HB comment "Protein disulfide-isomerase is an enzyme that in humans is encoded by the P4HB gene.This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen.".
- P4HB label "P4HB".
- P4HB sameAs P4HB.
- P4HB sameAs m.03gvk7w.
- P4HB sameAs Q7117911.
- P4HB sameAs Q7117911.
- P4HB sameAs 4240.
- P4HB wasDerivedFrom P4HB?oldid=597823399.
- P4HB isPrimaryTopicOf P4HB.