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- PAC-1 abstract "This article refers to the anti-tumor molecule, and not the a2iib3 integrin activation specific antibody of the same namePAC-1 (first procaspase activating compound) is a synthesized chemical compound that selectively induces apoptosis, or cell suicide, in cancerous cells. PAC-1 has shown good results in mouse models and is being further evaluated for use in humans. In 2010 a published study showed PAC-1 to be safe to research dogs, and a second study published later that same year reported that a PAC-1 derivative (called S-PAC-1) was well tolerated in a small Phase I Clinical Trial of pet dogs with lymphoma. Even at low doses of S-PAC-1, tumors regressed in 1/6 dogs, and the disease was stabilized (no additional tumor growth) in 3/6 dogs. In 2011 Vanquish Oncology Inc. was founded to move PAC-1 forward to a human clinical trial, and in 2013 Vanquish Oncology announced a multimillion dollar angel investment into the company.".
- PAC-1 casNumber "315183-21-2".
- PAC-1 fdaUniiCode "9LIS8N0B2C".
- PAC-1 iupacName "2-(4-benzylpiperazin-1-yl)-N-[(2-hydroxy-3-prop-".
- PAC-1 iupacName "2-enyl-phenyl)methylideneamino]acetamide".
- PAC-1 pubchem "1185541".
- PAC-1 thumbnail PAC-1.svg?width=300.
- PAC-1 wikiPageExternalLink 3670495.stm.
- PAC-1 wikiPageExternalLink 5284850.stm.
- PAC-1 wikiPageExternalLink 0717cancer_drug_PaulHergenrother_TimFan.html.
- PAC-1 wikiPageExternalLink vanquishoncology.com.
- PAC-1 wikiPageID "8427461".
- PAC-1 wikiPageRevisionID "592899412".
- PAC-1 c "23".
- PAC-1 casNumber "315183".
- PAC-1 chemspiderid "12272376".
- PAC-1 h "28".
- PAC-1 hasPhotoCollection PAC-1.
- PAC-1 inchi "1".
- PAC-1 inchikey "YQNRVGJCPCNMKT-JLPGSUDCBL".
- PAC-1 iupacName "2".
- PAC-1 molecularWeight "392.494".
- PAC-1 n "4".
- PAC-1 o "2".
- PAC-1 pubchem "1185541".
- PAC-1 smiles "C=CCc3ccccc3O".
- PAC-1 stdinchi "1".
- PAC-1 stdinchikey "YQNRVGJCPCNMKT-JLPGSUDCSA-N".
- PAC-1 unii "9".
- PAC-1 verifiedrevid "447720403".
- PAC-1 subject Category:Cell_signaling.
- PAC-1 subject Category:Experimental_cancer_drugs.
- PAC-1 subject Category:Immune_system.
- PAC-1 subject Category:Programmed_cell_death.
- PAC-1 type Drug.
- PAC-1 type DrugProduct.
- PAC-1 type FunctionalSubstance.
- PAC-1 comment "This article refers to the anti-tumor molecule, and not the a2iib3 integrin activation specific antibody of the same namePAC-1 (first procaspase activating compound) is a synthesized chemical compound that selectively induces apoptosis, or cell suicide, in cancerous cells. PAC-1 has shown good results in mouse models and is being further evaluated for use in humans.".
- PAC-1 label "PAC-1".
- PAC-1 sameAs m.02731w_.
- PAC-1 sameAs Q7118028.
- PAC-1 sameAs Q7118028.
- PAC-1 wasDerivedFrom PAC-1?oldid=592899412.
- PAC-1 depiction PAC-1.svg.
- PAC-1 isPrimaryTopicOf PAC-1.
