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- PAX5 abstract "Paired box protein Pax-5 is a protein that in humans is encoded by the PAX5 gene.The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. The PAX5 gene is located in chromosome 9p13 region, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoters, suggesting that the deregulation of PAX5 gene transcription contributes to the pathogenesis of these lymphomas. A transcript variant arising as a consequence of alternative promoter usage, and containing a different coding exon 1(B), has been described, however, its full-length nature is not known.".
- PAX5 entrezgene "5079".
- PAX5 wikiPageID "14754423".
- PAX5 wikiPageRevisionID "592757109".
- PAX5 hasPhotoCollection PAX5.
- PAX5 requireManualInspection "no".
- PAX5 summaryText "The PAX5 gene is a member of the paired box family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. The PAX5 gene is located in chromosome 9p13 region, which is involved in t translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoters, suggesting that the deregulation of PAX5 gene transcription contributes to the pathogenesis of these lymphomas. A transcript variant arising as a consequence of alternative promoter usage, and containing a different coding exon 1, has been described, however, its full-length nature is not known.".
- PAX5 updateCitations "yes".
- PAX5 updatePage "yes".
- PAX5 updateProteinBox "yes".
- PAX5 updateSummary "yes".
- PAX5 subject Category:Transcription_factors.
- PAX5 type Biomolecule.
- PAX5 type Protein.
- PAX5 type BiologicalObject.
- PAX5 comment "Paired box protein Pax-5 is a protein that in humans is encoded by the PAX5 gene.The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation.".
- PAX5 label "PAX5".
- PAX5 sameAs m.03gwr2p.
- PAX5 sameAs Q7118304.
- PAX5 sameAs Q7118304.
- PAX5 wasDerivedFrom PAX5?oldid=592757109.
- PAX5 isPrimaryTopicOf PAX5.