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- PCBP1 abstract "Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.".
- PCBP1 entrezgene "5093".
- PCBP1 wikiPageID "14168204".
- PCBP1 wikiPageRevisionID "592757731".
- PCBP1 hasPhotoCollection PCBP1.
- PCBP1 requireManualInspection "no".
- PCBP1 summaryText "This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly-binding protein. It contains three K-homologous domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.".
- PCBP1 updateCitations "yes".
- PCBP1 updatePage "yes".
- PCBP1 updateProteinBox "yes".
- PCBP1 updateSummary "yes".
- PCBP1 type Biomolecule.
- PCBP1 type Protein.
- PCBP1 type BiologicalObject.
- PCBP1 comment "Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein.".
- PCBP1 label "PCBP1".
- PCBP1 sameAs m.03cwphs.
- PCBP1 sameAs Q7118502.
- PCBP1 sameAs Q7118502.
- PCBP1 wasDerivedFrom PCBP1?oldid=592757731.
- PCBP1 isPrimaryTopicOf PCBP1.