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- PCDHA3 abstract "Protocadherin alpha-3 is a protein that in humans is encoded by the PCDHA3 gene.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.".
- PCDHA3 entrezgene "56145".
- PCDHA3 wikiPageID "16853902".
- PCDHA3 wikiPageRevisionID "592757888".
- PCDHA3 hasPhotoCollection PCDHA3.
- PCDHA3 requireManualInspection "no".
- PCDHA3 summaryText "This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.".
- PCDHA3 updateCitations "yes".
- PCDHA3 updatePage "yes".
- PCDHA3 updateProteinBox "yes".
- PCDHA3 updateSummary "yes".
- PCDHA3 type Biomolecule.
- PCDHA3 type Protein.
- PCDHA3 type BiologicalObject.
- PCDHA3 comment "Protocadherin alpha-3 is a protein that in humans is encoded by the PCDHA3 gene.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.".
- PCDHA3 label "PCDHA3".
- PCDHA3 sameAs m.0408g9k.
- PCDHA3 sameAs Q7118540.
- PCDHA3 sameAs Q7118540.
- PCDHA3 wasDerivedFrom PCDHA3?oldid=592757888.
- PCDHA3 isPrimaryTopicOf PCDHA3.