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- PCDHA5 abstract "Protocadherin alpha-5 is a protein that in humans is encoded by the PCDHA5 gene.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.".
- PCDHA5 entrezgene "56143".
- PCDHA5 wikiPageID "15352868".
- PCDHA5 wikiPageRevisionID "592757914".
- PCDHA5 hasPhotoCollection PCDHA5.
- PCDHA5 requireManualInspection "no".
- PCDHA5 summaryText "This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.".
- PCDHA5 updateCitations "yes".
- PCDHA5 updatePage "yes".
- PCDHA5 updateProteinBox "yes".
- PCDHA5 updateSummary "yes".
- PCDHA5 type Biomolecule.
- PCDHA5 type Protein.
- PCDHA5 type BiologicalObject.
- PCDHA5 comment "Protocadherin alpha-5 is a protein that in humans is encoded by the PCDHA5 gene.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.".
- PCDHA5 label "PCDHA5".
- PCDHA5 sameAs m.03m5yx7.
- PCDHA5 sameAs Q7118542.
- PCDHA5 sameAs Q7118542.
- PCDHA5 wasDerivedFrom PCDHA5?oldid=592757914.
- PCDHA5 isPrimaryTopicOf PCDHA5.