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- PCDHA6 abstract "Protocadherin alpha-6 is a protein that in humans is encoded by the PCDHA6 gene.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.".
- PCDHA6 entrezgene "56142".
- PCDHA6 wikiPageID "15220944".
- PCDHA6 wikiPageRevisionID "592757920".
- PCDHA6 hasPhotoCollection PCDHA6.
- PCDHA6 requireManualInspection "no".
- PCDHA6 summaryText "This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.".
- PCDHA6 updateCitations "yes".
- PCDHA6 updatePage "yes".
- PCDHA6 updateProteinBox "yes".
- PCDHA6 updateSummary "yes".
- PCDHA6 type Biomolecule.
- PCDHA6 type Protein.
- PCDHA6 type BiologicalObject.
- PCDHA6 comment "Protocadherin alpha-6 is a protein that in humans is encoded by the PCDHA6 gene.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.".
- PCDHA6 label "PCDHA6".
- PCDHA6 sameAs m.03hmbjx.
- PCDHA6 sameAs Q7118544.
- PCDHA6 sameAs Q7118544.
- PCDHA6 wasDerivedFrom PCDHA6?oldid=592757920.
- PCDHA6 isPrimaryTopicOf PCDHA6.