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- PCDHGA12 abstract "Protocadherin gamma-A12 is a protein that in humans is encoded by the PCDHGA12 gene.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.".
- PCDHGA12 entrezgene "26025".
- PCDHGA12 wikiPageID "16848832".
- PCDHGA12 wikiPageRevisionID "592758089".
- PCDHGA12 hasPhotoCollection PCDHGA12.
- PCDHGA12 requireManualInspection "no".
- PCDHGA12 summaryText "This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.".
- PCDHGA12 updateCitations "yes".
- PCDHGA12 updatePage "yes".
- PCDHGA12 updateProteinBox "yes".
- PCDHGA12 updateSummary "yes".
- PCDHGA12 type Biomolecule.
- PCDHGA12 type Protein.
- PCDHGA12 type BiologicalObject.
- PCDHGA12 comment "Protocadherin gamma-A12 is a protein that in humans is encoded by the PCDHGA12 gene.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies.".
- PCDHGA12 label "PCDHGA12".
- PCDHGA12 sameAs m.04087wv.
- PCDHGA12 sameAs Q7118563.
- PCDHGA12 sameAs Q7118563.
- PCDHGA12 wasDerivedFrom PCDHGA12?oldid=592758089.
- PCDHGA12 isPrimaryTopicOf PCDHGA12.