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- PCMT1 abstract "Protein-L-isoaspartate(D-aspartate) O-methyltransferase is an enzyme that in humans is encoded by the PCMT1 gene.Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.[supplied by OMIM]".
- PCMT1 entrezgene "5110".
- PCMT1 wikiPageID "14795522".
- PCMT1 wikiPageRevisionID "592758253".
- PCMT1 hasPhotoCollection PCMT1.
- PCMT1 requireManualInspection "no".
- PCMT1 summaryText "Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.[supplied by OMIM]".
- PCMT1 updateCitations "yes".
- PCMT1 updatePage "yes".
- PCMT1 updateProteinBox "yes".
- PCMT1 updateSummary "yes".
- PCMT1 type Biomolecule.
- PCMT1 type Protein.
- PCMT1 type BiologicalObject.
- PCMT1 comment "Protein-L-isoaspartate(D-aspartate) O-methyltransferase is an enzyme that in humans is encoded by the PCMT1 gene.Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues.".
- PCMT1 label "PCMT1".
- PCMT1 sameAs m.03gy5_9.
- PCMT1 sameAs Q7118620.
- PCMT1 sameAs Q7118620.
- PCMT1 sameAs 1998.
- PCMT1 wasDerivedFrom PCMT1?oldid=592758253.
- PCMT1 isPrimaryTopicOf PCMT1.