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- PDGFB abstract "Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene.The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.".
- PDGFB entrezgene "5155".
- PDGFB wikiPageID "14286331".
- PDGFB wikiPageRevisionID "592758860".
- PDGFB hasPhotoCollection PDGFB.
- PDGFB requireManualInspection "no".
- PDGFB summaryText "The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor alpha polypeptide , where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.".
- PDGFB updateCitations "yes".
- PDGFB updatePage "yes".
- PDGFB updateProteinBox "yes".
- PDGFB updateSummary "yes".
- PDGFB subject Category:Growth_factors.
- PDGFB type Abstraction100002137.
- PDGFB type Chemical114806838.
- PDGFB type Compound114818238.
- PDGFB type GrowthFactor114734348.
- PDGFB type GrowthFactors.
- PDGFB type Macromolecule114944888.
- PDGFB type Material114580897.
- PDGFB type Matter100020827.
- PDGFB type Molecule114682133.
- PDGFB type OrganicCompound114727670.
- PDGFB type Part113809207.
- PDGFB type PhysicalEntity100001930.
- PDGFB type Protein114728724.
- PDGFB type Relation100031921.
- PDGFB type Substance100019613.
- PDGFB type Thing100002452.
- PDGFB type Unit109465459.
- PDGFB type Biomolecule.
- PDGFB type Protein.
- PDGFB type BiologicalObject.
- PDGFB comment "Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene.The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines.".
- PDGFB label "PDGFB".
- PDGFB sameAs m.03c_d35.
- PDGFB sameAs Q7118813.
- PDGFB sameAs Q7118813.
- PDGFB sameAs PDGFB.
- PDGFB sameAs PDGFB.
- PDGFB wasDerivedFrom PDGFB?oldid=592758860.
- PDGFB isPrimaryTopicOf PDGFB.