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- PF-4800567 abstract "PF-4800567 is a drug developed by Pfizer which acts as a selective inhibitor of the enzyme Casein kinase 1 epsilon (CK1-ε), and has mainly been used in the study of the casein kinase 1 enzymes in the regulation of circadian rhythm, as well as showing potential neuroprotective effects. While this research has shown that circadian rhythm is modulated primarily by the alternate isoform CK1-δ rather than CK1-ε, both PF-4800567 and the related non-selective CK1-δ/ε inhibitor PF-670462 were found in animal studies to enhance responses to certain drugs of abuse such as methamphetamine and fentanyl, which suggests a role for CK1-ε in negative regulation of sensitivity to stimulant and opioid drugs.".
- PF-4800567 casNumber "1188296-52-7".
- PF-4800567 iupacName "3-(3-chloro-phenoxymethyl)-1-(tetrahydro-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine".
- PF-4800567 pubchem "53472153".
- PF-4800567 thumbnail PF-4800567_structure.png?width=300.
- PF-4800567 wikiPageID "34520849".
- PF-4800567 wikiPageRevisionID "474003632".
- PF-4800567 c "17".
- PF-4800567 casNumber "1188296".
- PF-4800567 cl "1".
- PF-4800567 h "18".
- PF-4800567 hasPhotoCollection PF-4800567.
- PF-4800567 iupacName "3".
- PF-4800567 molecularWeight "359.809".
- PF-4800567 n "5".
- PF-4800567 o "2".
- PF-4800567 pubchem "53472153".
- PF-4800567 smiles "c4ccccc4OCcnnC2CCOCC2".
- PF-4800567 width "240".
- PF-4800567 subject Category:Enzyme_inhibitors.
- PF-4800567 subject Category:Pfizer.
- PF-4800567 type Drug.
- PF-4800567 type FunctionalSubstance.
- PF-4800567 comment "PF-4800567 is a drug developed by Pfizer which acts as a selective inhibitor of the enzyme Casein kinase 1 epsilon (CK1-ε), and has mainly been used in the study of the casein kinase 1 enzymes in the regulation of circadian rhythm, as well as showing potential neuroprotective effects.".
- PF-4800567 label "PF-4800567".
- PF-4800567 sameAs m.0j2883v.
- PF-4800567 sameAs Q7119049.
- PF-4800567 sameAs Q7119049.
- PF-4800567 wasDerivedFrom PF-4800567?oldid=474003632.
- PF-4800567 depiction PF-4800567_structure.png.
- PF-4800567 isPrimaryTopicOf PF-4800567.
