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- PIAS3 abstract "E3 SUMO-protein ligase PIAS3 is an enzyme that in humans is encoded by the PIAS3 gene.PIAS proteins were originally identified in studies that were aimed to decipher the Janus Kinase (JAK)/STAT signaling pathway. The mammalian PIAS family consists of four members: PIAS1, PIAS2, PIAS3 and PIAS4. In Drosophila, a single PIAS homologue named dPIAS/Zimp has been identified. In yeast, two PIAS-related proteins were identified namely SIZ1 and SIZ2. Studies by different research groups have now identified a rapidly growing list of more than 60 proteins, most of them transcription factors that can be either positively or negatively regulated by members of the PIAS family through multiple mechanisms.Originally, PIAS3 was found to interact specifically with phosphorylated STAT3 in Interleukin -6 (IL-6) activated murine myeloblast M1 cells. This interaction is mediated via PIAS3 binding to the STAT3 DNA binding domain. Hence, STAT3 transcriptional activity is inhibited by the physical prevention of its binding to target genes. Subsequently, PIAS3 was also found to be a regulator protein of other key transcription factors, including MITF, NFκB, SMAD and estrogen receptor.PIAS3 protein also functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.".
- PIAS3 entrezgene "10401".
- PIAS3 wikiPageID "14759875".
- PIAS3 wikiPageRevisionID "592793884".
- PIAS3 hasPhotoCollection PIAS3.
- PIAS3 requireManualInspection "no".
- PIAS3 summaryText "PIAS3 protein also functions as a SUMO -E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.".
- PIAS3 updateCitations "yes".
- PIAS3 updatePage "yes".
- PIAS3 updateProteinBox "yes".
- PIAS3 updateSummary "yes".
- PIAS3 type Biomolecule.
- PIAS3 type Protein.
- PIAS3 type BiologicalObject.
- PIAS3 comment "E3 SUMO-protein ligase PIAS3 is an enzyme that in humans is encoded by the PIAS3 gene.PIAS proteins were originally identified in studies that were aimed to decipher the Janus Kinase (JAK)/STAT signaling pathway. The mammalian PIAS family consists of four members: PIAS1, PIAS2, PIAS3 and PIAS4. In Drosophila, a single PIAS homologue named dPIAS/Zimp has been identified. In yeast, two PIAS-related proteins were identified namely SIZ1 and SIZ2.".
- PIAS3 label "PIAS3".
- PIAS3 sameAs m.03gw_nf.
- PIAS3 sameAs Q7119299.
- PIAS3 sameAs Q7119299.
- PIAS3 wasDerivedFrom PIAS3?oldid=592793884.
- PIAS3 isPrimaryTopicOf PIAS3.