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- PILRB abstract "Paired immunoglobulin-like type 2 receptor beta is a protein that in humans is encoded by the PILRB gene.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.".
- PILRB entrezgene "29990".
- PILRB wikiPageID "15246056".
- PILRB wikiPageRevisionID "592797839".
- PILRB hasPhotoCollection PILRB.
- PILRB requireManualInspection "no".
- PILRB summaryText "Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif -bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.".
- PILRB updateCitations "yes".
- PILRB updatePage "yes".
- PILRB updateProteinBox "yes".
- PILRB updateSummary "yes".
- PILRB type Biomolecule.
- PILRB type Protein.
- PILRB type BiologicalObject.
- PILRB comment "Paired immunoglobulin-like type 2 receptor beta is a protein that in humans is encoded by the PILRB gene.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways.".
- PILRB label "PILRB".
- PILRB sameAs m.03hn3s9.
- PILRB sameAs Q7119393.
- PILRB sameAs Q7119393.
- PILRB wasDerivedFrom PILRB?oldid=592797839.
- PILRB isPrimaryTopicOf PILRB.