Matches in DBpedia 2014 for { <http://dbpedia.org/resource/PLAU> ?p ?o. }
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- PLAU abstract "Urokinase-type plasminogen activator is an enzyme that in humans is encoded by the PLAU gene.This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.".
- PLAU entrezgene "5328".
- PLAU wikiPageID "14005159".
- PLAU wikiPageRevisionID "592813922".
- PLAU hasPhotoCollection PLAU.
- PLAU requireManualInspection "no".
- PLAU summaryText "This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA . HMW-uPA can be further processed into LMW-uPA by cleavage of chain A into a short chain A and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.".
- PLAU updateCitations "yes".
- PLAU updatePage "yes".
- PLAU updateProteinBox "yes".
- PLAU updateSummary "yes".
- PLAU type Biomolecule.
- PLAU type Protein.
- PLAU type BiologicalObject.
- PLAU comment "Urokinase-type plasminogen activator is an enzyme that in humans is encoded by the PLAU gene.This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen.".
- PLAU label "PLAU".
- PLAU sameAs PLAU.
- PLAU sameAs m.03cqs5l.
- PLAU sameAs Q7119591.
- PLAU sameAs Q7119591.
- PLAU sameAs PLAU.
- PLAU sameAs 1074.
- PLAU wasDerivedFrom PLAU?oldid=592813922.
- PLAU isPrimaryTopicOf PLAU.