Matches in DBpedia 2014 for { <http://dbpedia.org/resource/PPM1A> ?p ?o. }
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- PPM1A abstract "Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described.".
- PPM1A entrezgene "5494".
- PPM1A wikiPageID "14771764".
- PPM1A wikiPageRevisionID "592840508".
- PPM1A hasPhotoCollection PPM1A.
- PPM1A requireManualInspection "no".
- PPM1A summaryText "The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described.".
- PPM1A updateCitations "yes".
- PPM1A updatePage "yes".
- PPM1A updateProteinBox "yes".
- PPM1A updateSummary "yes".
- PPM1A type Biomolecule.
- PPM1A type Protein.
- PPM1A type BiologicalObject.
- PPM1A comment "Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses.".
- PPM1A label "PPM1A".
- PPM1A sameAs m.03gxgk2.
- PPM1A sameAs Q7120131.
- PPM1A sameAs Q7120131.
- PPM1A wasDerivedFrom PPM1A?oldid=592840508.
- PPM1A isPrimaryTopicOf PPM1A.