Matches in DBpedia 2014 for { <http://dbpedia.org/resource/PPM1D> ?p ?o. }
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- PPM1D abstract "Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene.The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase (MAPK/p38) through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.".
- PPM1D entrezgene "8493".
- PPM1D wikiPageExternalLink nature377_3.pdf.
- PPM1D wikiPageID "14763685".
- PPM1D wikiPageRevisionID "592840546".
- PPM1D hasPhotoCollection PPM1D.
- PPM1D requireManualInspection "no".
- PPM1D summaryText "The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.".
- PPM1D updateCitations "yes".
- PPM1D updatePage "yes".
- PPM1D updateProteinBox "yes".
- PPM1D updateSummary "yes".
- PPM1D type Biomolecule.
- PPM1D type Protein.
- PPM1D type BiologicalObject.
- PPM1D comment "Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene.The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses.".
- PPM1D label "PPM1D".
- PPM1D sameAs m.03gx5rf.
- PPM1D sameAs Q7120127.
- PPM1D sameAs Q7120127.
- PPM1D sameAs PPM1D.
- PPM1D wasDerivedFrom PPM1D?oldid=592840546.
- PPM1D isPrimaryTopicOf PPM1D.