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- PRC1 abstract "Protein Regulator of cytokinesis 1 (PRC1) is a protein that in humans is encoded by the PRC1 gene and is involved in cytokinesis.PRC1 protein is expressed at relatively high levels during S and G2/M phases of the cell cycle before dropping dramatically after mitotic exit and entrance into G1 phase. PRC1 is located in the nucleus during interphase, becomes associated with the mitotic spindle in a highly dynamic manner during anaphase, and localizes to the cell midbody during cytokinesis. Shown to be a substrate of several cyclin-dependent kinases (CDKs), PRC1 has become a novel human protein of cytokinetic importance since its identification in 1998. Correspondingly, ablation of PRC1 has been shown to disrupt spindle midzone assembly in mammalian systems.At least three alternatively spliced transcript variants encoding distinct isoforms of PRC1 have been observed. Additionally, PRC1 has sequence homology with Ase1 in yeasts, SPD-1 (spindle defective 1) in C. elegans, Feo in D. melanogaster, and MAP65 in plants, all of which fall in a conserved family of nonmotor microtubule-associated proteins (MAPs).".
- PRC1 entrezgene "9055".
- PRC1 wikiPageID "14879032".
- PRC1 wikiPageRevisionID "600789049".
- PRC1 hasPhotoCollection PRC1.
- PRC1 requireManualInspection "no".
- PRC1 summaryText "PRC1 protein is expressed at relatively high levels during S and G2/M phases of the cell cycle before dropping dramatically after mitotic exit and entrance into G1 phase. PRC1 is located in the nucleus during interphase, becomes associated with the mitotic spindle in a highly dynamic manner during anaphase, and localizes to the cell midbody during cytokinesis. Shown to be a substrate of several cyclin-dependent kinases , PRC1 has become a novel human protein of cytokinetic importance since its identification in 1998. Correspondingly, ablation of PRC1 has been shown to disrupt spindle midzone assembly in mammalian systems. At least three alternatively spliced transcript variants encoding distinct isoforms of PRC1 have been observed. Additionally, PRC1 has sequence homology with Ase1 in yeasts, SPD-1 in C. elegans, Feo in D. melanogaster, and MAP65 in plants, all of which fall in a conserved family of nonmotor microtubule-associated proteins .".
- PRC1 updateCitations "yes".
- PRC1 updatePage "yes".
- PRC1 updateProteinBox "yes".
- PRC1 updateSummary "yes".
- PRC1 type Biomolecule.
- PRC1 type Protein.
- PRC1 type BiologicalObject.
- PRC1 comment "Protein Regulator of cytokinesis 1 (PRC1) is a protein that in humans is encoded by the PRC1 gene and is involved in cytokinesis.PRC1 protein is expressed at relatively high levels during S and G2/M phases of the cell cycle before dropping dramatically after mitotic exit and entrance into G1 phase. PRC1 is located in the nucleus during interphase, becomes associated with the mitotic spindle in a highly dynamic manner during anaphase, and localizes to the cell midbody during cytokinesis.".
- PRC1 label "PRC1".
- PRC1 sameAs m.03h01zt.
- PRC1 sameAs Q7120260.
- PRC1 sameAs Q7120260.
- PRC1 wasDerivedFrom PRC1?oldid=600789049.
- PRC1 isPrimaryTopicOf PRC1.