Matches in DBpedia 2014 for { <http://dbpedia.org/resource/PRKAA2> ?p ?o. }
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- PRKAA2 abstract "5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene.The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.".
- PRKAA2 entrezgene "5563".
- PRKAA2 wikiPageID "14725841".
- PRKAA2 wikiPageRevisionID "592853781".
- PRKAA2 hasPhotoCollection PRKAA2.
- PRKAA2 requireManualInspection "no".
- PRKAA2 summaryText "The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase and beta-hydroxy beta-methylglutaryl-CoA reductase , key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.".
- PRKAA2 updateCitations "yes".
- PRKAA2 updatePage "yes".
- PRKAA2 updateProteinBox "yes".
- PRKAA2 updateSummary "yes".
- PRKAA2 type Biomolecule.
- PRKAA2 type Protein.
- PRKAA2 type BiologicalObject.
- PRKAA2 comment "5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene.The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status.".
- PRKAA2 label "PRKAA2".
- PRKAA2 sameAs PRKAA2.
- PRKAA2 sameAs m.03gvpfg.
- PRKAA2 sameAs Q7120323.
- PRKAA2 sameAs Q7120323.
- PRKAA2 wasDerivedFrom PRKAA2?oldid=592853781.
- PRKAA2 isPrimaryTopicOf PRKAA2.