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- PRKAB1 abstract "5'-AMP-activated protein kinase subunit beta-1 is an enzyme that in humans is encoded by the PRKAB1 gene.The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.".
- PRKAB1 entrezgene "5564".
- PRKAB1 symbol "AMPKBI".
- PRKAB1 wikiPageID "14754244".
- PRKAB1 wikiPageRevisionID "592853805".
- PRKAB1 caption "crystal structure of the adenylate sensor from amp-activated protein kinase complexed with atp".
- PRKAB1 hasPhotoCollection PRKAB1.
- PRKAB1 interpro "IPR006828".
- PRKAB1 name "AMPKBI".
- PRKAB1 pfam "PF04739".
- PRKAB1 requireManualInspection "no".
- PRKAB1 summaryText "The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase and beta-hydroxy beta-methylglutaryl-CoA reductase , key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.".
- PRKAB1 symbol "AMPKBI".
- PRKAB1 updateCitations "yes".
- PRKAB1 updatePage "yes".
- PRKAB1 updateProteinBox "yes".
- PRKAB1 updateSummary "yes".
- PRKAB1 subject Category:Genes_mutated_in_mice.
- PRKAB1 type Biomolecule.
- PRKAB1 type Protein.
- PRKAB1 type BiologicalObject.
- PRKAB1 comment "5'-AMP-activated protein kinase subunit beta-1 is an enzyme that in humans is encoded by the PRKAB1 gene.The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status.".
- PRKAB1 label "PRKAB1".
- PRKAB1 sameAs PRKAB1.
- PRKAB1 sameAs m.03gwqm5.
- PRKAB1 sameAs Q7120324.
- PRKAB1 sameAs Q7120324.
- PRKAB1 sameAs 281.
- PRKAB1 wasDerivedFrom PRKAB1?oldid=592853805.
- PRKAB1 isPrimaryTopicOf PRKAB1.