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- PSMA7 abstract "Proteasome subunit alpha type-7 is a protein that in humans is encoded by the PSMA7 gene.The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9.".
- PSMA7 entrezgene "5688".
- PSMA7 wikiPageID "14753885".
- PSMA7 wikiPageRevisionID "592871840".
- PSMA7 hasPhotoCollection PSMA7.
- PSMA7 requireManualInspection "no".
- PSMA7 summaryText "The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9.".
- PSMA7 updateCitations "yes".
- PSMA7 updatePage "yes".
- PSMA7 updateProteinBox "yes".
- PSMA7 updateSummary "yes".
- PSMA7 type Biomolecule.
- PSMA7 type Protein.
- PSMA7 type BiologicalObject.
- PSMA7 comment "Proteasome subunit alpha type-7 is a protein that in humans is encoded by the PSMA7 gene.The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits.".
- PSMA7 label "PSMA7".
- PSMA7 sameAs m.03gwpr_.
- PSMA7 sameAs Q7120693.
- PSMA7 sameAs Q7120693.
- PSMA7 wasDerivedFrom PSMA7?oldid=592871840.
- PSMA7 isPrimaryTopicOf PSMA7.