Matches in DBpedia 2014 for { <http://dbpedia.org/resource/PSMB8> ?p ?o. }
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- PSMB8 abstract "Proteasome subunit beta type-8 is a protein that in humans is encoded by the PSMB8 gene.The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 14 non-identical subunits; 2 rings are composed of 7 different alpha subunits and 2 rings are composed of 7 different beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.".
- PSMB8 entrezgene "5696".
- PSMB8 wikiPageID "14723094".
- PSMB8 wikiPageRevisionID "601783665".
- PSMB8 hasPhotoCollection PSMB8.
- PSMB8 requireManualInspection "no".
- PSMB8 summaryText "The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 14 non-identical subunits; 2 rings are composed of 7 different alpha subunits and 2 rings are composed of 7 different beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC . Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.".
- PSMB8 updateCitations "yes".
- PSMB8 updatePage "yes".
- PSMB8 updateProteinBox "yes".
- PSMB8 updateSummary "yes".
- PSMB8 type Biomolecule.
- PSMB8 type Protein.
- PSMB8 type BiologicalObject.
- PSMB8 comment "Proteasome subunit beta type-8 is a protein that in humans is encoded by the PSMB8 gene.The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 14 non-identical subunits; 2 rings are composed of 7 different alpha subunits and 2 rings are composed of 7 different beta subunits.".
- PSMB8 label "PSMB8".
- PSMB8 sameAs m.03gvkb8.
- PSMB8 sameAs Q7120703.
- PSMB8 sameAs Q7120703.
- PSMB8 wasDerivedFrom PSMB8?oldid=601783665.
- PSMB8 isPrimaryTopicOf PSMB8.