Matches in DBpedia 2014 for { <http://dbpedia.org/resource/PSMC1> ?p ?o. }
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- PSMC1 abstract "26S protease regulatory subunit 4 is an enzyme that in humans is encoded by the PSMC1 gene.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.".
- PSMC1 entrezgene "5700".
- PSMC1 wikiPageID "14753899".
- PSMC1 wikiPageRevisionID "592872036".
- PSMC1 hasPhotoCollection PSMC1.
- PSMC1 requireManualInspection "no".
- PSMC1 summaryText "The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.".
- PSMC1 updateCitations "yes".
- PSMC1 updatePage "yes".
- PSMC1 updateProteinBox "yes".
- PSMC1 updateSummary "yes".
- PSMC1 type Biomolecule.
- PSMC1 type Protein.
- PSMC1 type BiologicalObject.
- PSMC1 comment "26S protease regulatory subunit 4 is an enzyme that in humans is encoded by the PSMC1 gene.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits.".
- PSMC1 label "PSMC1".
- PSMC1 sameAs m.03gwpt0.
- PSMC1 sameAs Q7120705.
- PSMC1 sameAs Q7120705.
- PSMC1 wasDerivedFrom PSMC1?oldid=592872036.
- PSMC1 isPrimaryTopicOf PSMC1.