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- PSMC3 abstract "26S protease regulatory subunit 6A is an enzyme that in humans is encoded by the PSMC3 gene.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.".
- PSMC3 entrezgene "5702".
- PSMC3 wikiPageID "14138517".
- PSMC3 wikiPageRevisionID "592872071".
- PSMC3 hasPhotoCollection PSMC3.
- PSMC3 requireManualInspection "no".
- PSMC3 summaryText "The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.".
- PSMC3 updateCitations "yes".
- PSMC3 updatePage "yes".
- PSMC3 updateProteinBox "yes".
- PSMC3 updateSummary "yes".
- PSMC3 type Biomolecule.
- PSMC3 type Protein.
- PSMC3 type BiologicalObject.
- PSMC3 comment "26S protease regulatory subunit 6A is an enzyme that in humans is encoded by the PSMC3 gene.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits.".
- PSMC3 label "PSMC3".
- PSMC3 sameAs m.03cvrqq.
- PSMC3 sameAs Q7120707.
- PSMC3 sameAs Q7120707.
- PSMC3 wasDerivedFrom PSMC3?oldid=592872071.
- PSMC3 isPrimaryTopicOf PSMC3.