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- PSMD4 abstract "26S proteasome non-ATPase regulatory subunit 4 is an enzyme that in humans is encoded by the PSMD4 gene.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.".
- PSMD4 entrezgene "5710".
- PSMD4 wikiPageID "14724029".
- PSMD4 wikiPageRevisionID "592872304".
- PSMD4 hasPhotoCollection PSMD4.
- PSMD4 requireManualInspection "no".
- PSMD4 summaryText "The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.".
- PSMD4 updateCitations "yes".
- PSMD4 updatePage "yes".
- PSMD4 updateProteinBox "yes".
- PSMD4 updateSummary "yes".
- PSMD4 type Biomolecule.
- PSMD4 type Protein.
- PSMD4 type BiologicalObject.
- PSMD4 comment "26S proteasome non-ATPase regulatory subunit 4 is an enzyme that in humans is encoded by the PSMD4 gene.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits.".
- PSMD4 label "PSMD4".
- PSMD4 sameAs PSMD4.
- PSMD4 sameAs m.03gvly_.
- PSMD4 sameAs Q7120720.
- PSMD4 sameAs Q7120720.
- PSMD4 wasDerivedFrom PSMD4?oldid=592872304.
- PSMD4 isPrimaryTopicOf PSMD4.